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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282X


SILVA, Luciana Alvarenga da; SIQUEIRA, José Tadeu Tesseroli de; TEIXEIRA, Manoel Jacobsen  and  SIQUEIRA, Silvia Regina Dowgan Tesseroli de. The role of xerostomia in burning mouth syndrome: a case-control study. Arq. Neuro-Psiquiatr. [online]. 2014, vol.72, n.2, pp.91-98. ISSN 0004-282X.


: To assess the efficacy of anti-xerostomic topical medication (urea 10%) in patients with burning mouth syndrome (BMS).


: Thirty-eight subjects diagnosed with BMS according to the International Association for the Study of Pain guidelines were randomized to either placebo (5% sodium carboxymethylcellulose, 0.15% methyl paraben, and 10% glycerol in distilled water qsp 100 g) or treatment (urea 10%) to be applied to the oral cavity 3-4 times per day for 3 months. The patients were evaluated before and after treatment with the following instruments: the EDOF-HC protocol (Orofacial Pain Clinic – Hospital das Clínicas), a xerostomia questionnaire, and quantitative sensory testing.


: There were no differences in salivary flow or gustative, olfactory, or sensory thresholds (P>0.05). Fifteen (60%) patients reported improvement with the treatments (P=0.336).


: In conclusion, there were no differences between groups, and both exhibited an association between reported improvement and salivation.

Keywords : xerostomia; salivary flow; orofacial pain; quantitative sensory testing; burning mouth syndrome.

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