The use of oral anticoagulation treatment (OAT) in patients with an international normalized ratio (INR) higher than 1.7 is a contraindication to thrombolysis in acute ischemic stroke. The aim of the present study is to compare the use of point-of-care (POC) coagulometers to the standard coagulation analysis (SCA) procedure of the INR as a decision-making test for use with patients taking OAT.
Method:
Eighty patients on chronic OAT underwent a POC and an SCA during a regular outpatient evaluation.
Results:
When comparing the abilities of the POC test and the SCA test to identify adequate levels for thrombolysis (≤1.7), the POC had a sensitivity of 96.6% (95%CI 88.4-99.1) and a specificity of 60.0% (95%CI 38.6-78). POC overestimated INR levels by 0.51 points compared to the SCA test.
Conclusion:
POC has a high sensitivity compared to the SCA test for the identification of patients within the cut-off point for thrombolysis.
ischemic stroke; thrombolytic therapy; warfarin; contraindications; anticoagulation