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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282XOn-line version ISSN 1678-4227

Abstract

PASCHOAL JUNIOR, Fernando Mendes et al. Cerebral hemodynamic and metabolic changes in fulminant hepatic failure. Arq. Neuro-Psiquiatr. [online]. 2017, vol.75, n.7, pp.470-476. ISSN 0004-282X.  https://doi.org/10.1590/0004-282x20170076.

Intracranial hypertension and brain swelling are a major cause of morbidity and mortality of patients suffering from fulminant hepatic failure (FHF). The pathogenesis of these complications has been investigated in man, in experimental models and in isolated cell systems. Currently, the mechanism underlying cerebral edema and intracranial hypertension in the presence of FHF is multi-factorial in etiology and only partially understood. The aim of this paper is to review the pathophysiology of cerebral hemodynamic and metabolism changes in FHF in order to improve understanding of intracranial dynamics complication in FHF.

Keywords : hepatic insufficiency; intracranial hypertension; brain edema.

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