SciELO - Scientific Electronic Library Online

 
vol.75 issue11Conservative therapeutic management of carpal tunnel syndromeRequiem for a neurologist: the funeral rites of Jean-Martin Charcot author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

Share


Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282XOn-line version ISSN 1678-4227

Abstract

CARVALHO, Vitor Martinez de; NOGUEIRA, Eduardo de Almeida Guimarães; ROSA, Gleysson Rodrigues  and  FRAGOSO, Yara Dadalti. Mary Broadfoot Walker: 83 years since a historical discovery. Arq. Neuro-Psiquiatr. [online]. 2017, vol.75, n.11, pp.825-826. ISSN 0004-282X.  http://dx.doi.org/10.1590/0004-282x20170138.

Mary Broadfoot Walker was a Scottish physician who, in 1935, described in great detail the effect of an anticholinesterase drug (physostigmine) on the signs and symptoms of myasthenia gravis. An original five-minutes movie is available online and the skepticism of her contemporary British medical doctors is understandable when the drastic effect of the treatment is shown in this movie. What Mary Walker taught us, more than eight decades ago, about myasthenia gravis continues to be the basis of a pharmacological diagnostic test and treatment of this disease.

Keywords : myasthenia gravis; physostigmine; neostigmine; acetylcholinesterase.

        · abstract in Portuguese     · text in English     · English ( pdf )