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Jornal de Pediatria

Print version ISSN 0021-7557On-line version ISSN 1678-4782


PINTO, Ana Yecê das Neves; VENTURA, Ana Maria Revorêdo da Silva  and  SOUZA, José Maria de. IgG antibody response against Plasmodium vivax in children exposed to malaria before and after specific treatment. J. Pediatr. (Rio J.) [online]. 2001, vol.77, n.4, pp.299-306. ISSN 0021-7557.

OBJECTIVE: To assess the IgG antibody response against P. vivax (IgG anti-PV), and cytophilic (IgG1 and IgG3) and noncytophilic (IgG2) IgG subclasses in 34 children aged 0 to 15 years old infected with P. vivax malaria. METHODS: IgG levels were determined by indirect fluorescent antibody technique during the acute and therapeutic control phase. Patients were distributed into 2 groups according to the presence or absence of a previous malaria episode. IgG anti-PV levels were measured on the first and last day of treatment, and compared by Student's t test. Antibody levels were correlated with asexual parasitemia (Spearman's correlation test). RESULTS AND CONCLUSIONS : Increased IgG levels were observed on the first and on the last day of treatment. The geometric means for IgG subclass titers found in patients with previous history of malaria were: IgG1 (806.35) > IgG3 (28.28) > IgG2 (20). In patients infected for the first time, the responses obtained were: IgG1 (709.21) > IgG3 (39.3) > IgG2 (10.7). There was no association between asexual parasitemia and antibody levels on the first day of treatment. Cytophilic antibodies (IgG1, IgG3) predominated over noncytophilic antibodies (IgG2).

Keywords : vivax malaria; antibodies IgC; cytophilic antibodies; children.

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