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Jornal de Pediatria
Print version ISSN 0021-7557
ROSA-BORGES, Abertina et al. Glucose-6-phosphate dehydrogenase deficiency with recurrent infections: case report. J. Pediatr. (Rio J.) [online]. 2001, vol.77, n.4, pp. 331-336. ISSN 0021-7557. http://dx.doi.org/10.1590/S0021-75572001000400017.
OBJECTIVE: To report a case of rare neutrophil functional disorder with clinical and laboratory findings similar to those of chronic granulomatous disease. METHODS: Patient with extremely reduced level of glucose-6-phosphate dehydrogenase and recurrent infections that improved after continuous use of cotrimoxazole. The patient presented leukocytes with defective respiratory burst, similar to what occurs in chronic granulomatous disease. COMMENTS: The diagnosis of glucose-6-phosphate dehydrogenase deficiency in neutrophils should be considered in any patient with hemolytic anemia whose level of G6PD is extremely low or in any patient that presents recurrent infections as differential diagnosis of chronic granulomatous disease.
Keywords : glucosephosphate dehydrogenase deficiency; immunodeficiency syndromes; chronic granulomatous disease; neutrophilis; congenital hemolytic anemia.