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Jornal de Pediatria
On-line version ISSN 1678-4782
CASTRO JR, Cláudio Galvão de; GREGIANIN, Lauro José and BRUNETTO, Algemir Lunardi. Bone marrow transplantation and cord blood transplantation in children. J. Pediatr. (Rio J.) [online]. 2001, vol.77, n.5, pp. 345-360. ISSN 1678-4782. http://dx.doi.org/10.1590/S0021-75572001000500004.
OBJECTIVE: to review the indications, main steps and complications of bone marrow transplantation in children. SOURCES: medline-based literature review. SUMMARY OF THE FINDINGS: we comment about the indications of autologous, allogeneic and syngeneic bone marrow transplantation, donor selections, harvest and infusion of the hematopoietic progenitor cells that will reconstitute the hematopoietic and immune systems. We describe the different conditioning regimens and the new sources of cells, such as cord blood. We also describe the most common events after the procedure, including infections, graft versus host disease, and cardiovascular, pulmonary, hepatic, genitourinary, and gastrointestinal complications. The late effects and their impact on quality of life are also discussed. CONCLUSIONS: bone marrow transplantation does not confer an absolutely normal life span to all the patients; however, it represents the only chance of cure for children with certain neoplastic or immunological diseases. By knowing the steps of the procedure, pediatricians can be a source of information on bone marrow transplantation to the patients and their families.
Keywords : bone marrow transplantation; pediatric cancer; umbilical cord blood.