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Jornal de Pediatria
On-line version ISSN 1678-4782
SILVA, Elianete B.; GROTTO, Helena Z.W. and VILELA, Maria Marluce S.. Clinical aspects and complete blood counts in children exposed to HIV-1: comparison between infected patients and seroreverters. J. Pediatr. (Rio J.) [online]. 2001, vol.77, n.6, pp. 503-511. ISSN 1678-4782. http://dx.doi.org/10.1590/S0021-75572001000600014.
OBJECTIVE: to analyze the evolution of clinical and hematological aspects of children exposed to the vertical transmission of HIV-1, comparing infected patients with uninfected ones or seroreverters. METHODS: prospective, descriptive, longitudinal study. We analyzed 79 children born from HIV-1 infected mothers, under clinical follow up from March, 1996 until November, 1997, at the Immunodeficiency division of the Hospital de Clínicas da Unicamp (State University Hospital of Campinas). RESULTS: failure to thrive was observed in both groups, but was greater among seroreverters. Among the infected children, 23 mothers did not use AZT during pregnancy, 16 of them (61.5%) had been breastfed, four were classified into clinical category N, seven into A and fifteen into B. Clinical manifestations in patients younger than one year were seen in 18 infected children (69.2%). Anemia was observed in 73.1% of the infected group and in 41.5% of the seroreverters (P < 0.008). The comparison between the groups showed that the most common hematologic alterations in the infected children was microcytosis and hypochromia (P < 0.05), lymphopenia between 15 and 18 months (P < 0.05), monocytosis between 9 and 12 months (P < 0.05) and a tendency towards high ferritin levels, with no statistical significance. CONCLUSIONS: microcytic and hypochromic anemia were observed in both groups: iron deficiency in the uninfected children, and chronic disease anemia in the infected ones. The infected children presented with monocytosis and lymphopenia at an earlier stage.
Keywords : acquired immunodeficiency syndrome; anemia; lymphopenia.