SciELO - Scientific Electronic Library Online

vol.78 número5Evaluation of the nutritional status of Indian children from Alto Xingu, BrazilChanges in placental morphology of small for gestational age newborns índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados




Links relacionados


Jornal de Pediatria

versión impresa ISSN 0021-7557versión On-line ISSN 1678-4782


FAGUNDES, Eleonora D.T. et al. Diagnostic screening of liver disease in cystic fibrosis. J. Pediatr. (Rio J.) [online]. 2002, vol.78, n.5, pp.389-396. ISSN 0021-7557.

Objective: to determine the prevalence of clinical and biochemical abnormalities suggestive of liver disease in the population of patients with cystic fibrosis (CF) seen at the CF Outpatient Clinic of the Federal University of Minas Gerais; to describe the group of patients with liver disease and to compare it with the group without liver disease, regarding several clinical and laboratory variables. Methods: descriptive study, resultant of a prospective, and partially retrospective assessment of 106 patients with CF. Liver disease was defined by the presence of firm hepatomegaly (>2.5 cm from the right costal margin), and/or splenomegaly, and/or persistent and significant increase (>1.5 times the upper limit of normality, over six months) of at least two serum liver enzymes (alanine aminotransferase - ALT, aspartate aminotransferase - AST, alkaline phosphatase - ALP, -glutamyl transpeptidase - GGT). Results: hepatomegaly was verified in seven patients (6.6%) and splenomegaly in five (4.7%). AST activity was altered in 18.9% of the patients, ALT in 9.4%, GGT in 11.3%, and ALP in 46.2%. Significant and persistent increase in liver enzyme activities was verified in nine patients (8.5%). Ten patients with CF (9.4%) fulfill the criteria for liver disease. Other causes of liver disease were excluded. The mean age of the patients with liver disease was 7.7 years. There was absolute predominance of the male sex. All the patients are without symptoms. Conclusions: The prevalence of liver disease associated with CF was 9.4%. The frequent and transitory insignificant elevations of liver enzymes are well documented in the literature. Its significance as a predictor of liver disease has not been determined yet. However, the results of this study enhance the need for longitudinal assessment in order to define cases of liver disease in CF.

Palabras clave : cystic fibrosis; liver disease; prevalence.

        · resumen en Portugués     · texto en Portugués     · Portugués ( pdf epdf )


Creative Commons License Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons