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Jornal de Pediatria
On-line version ISSN 1678-4782
LAKS, Dani; LONGHI, Fernanda; WAGNER, Mário Bernardes and GARCIA, Pedro Celiny Ramos. Survival evaluation of children with acute lymphoblastic leukemia treated with Berlim-Frankfurt-Munich trial. J. Pediatr. (Rio J.) [online]. 2003, vol.79, n.2, pp. 149-158. ISSN 1678-4782. http://dx.doi.org/10.1590/S0021-75572003000200010.
OBJECTIVE: to determine the survival rate of children with acute lymphoblastic leukemia treated in Hospital São Lucas - Pontifícia Universidade Católica - Rio Grande do Sul during the past 10 years. To evaluate well known prognostic factors and to compare results of BFM 90 and 95 trials. METHODS: mixed cohort study of 0 to 15-years-old children treated with BFM 90 and 95 trials during the past 10 years at Hospital São Lucas - Pontifícia Universidade Católica - Rio Grande do Sul. Data were obtained from medical records. The occurrence of death was described by Kaplan-Meier survival curves. The overall effect of the prognostic factors was evaluated using the Cox's multivariate model. RESULTS: sixty three patients, whose mean age ( standard-deviation) was 6.3 4.2 years, were included. Thirty five patients (55.6%) were female. The estimated probability of relapse free survival at 5 years ( standard-error) was 50.8 7.2% for all patients, with 77.7 9.9% in the standard risk group, 41.3 15.4% in the intermediate risk group, and 39.3 13.7% in high risk group. CONCLUSIONS: the estimated probability of relapse free survival was below the results in developed countries. However the standard risk group obtained better prognostic but the small number of the cases doesn't allow permanent conclusions.
Keywords : leukemia, lymphocytic, acute; survival analysis.