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Jornal de Pediatria
On-line version ISSN 1678-4782
BRICKS, Lucia F.. Percutaneous or intradermal BCG vaccine?. J. Pediatr. (Rio J.) [online]. 2004, vol.80, n.2, pp. 93-98. ISSN 1678-4782. http://dx.doi.org/10.1590/S0021-75572004000200004.
OBJECTIVE: To compare the intradermal and percutaneous routes of BCG administration. SOURCES OF DATA: A review of the literature published between 1987 and 2002 was carried out in the MEDLINE and Lilacs databases. The following key words were used: BCG vaccine/administration, adverse effects, efficacy, tuberculosis/ prevention and control. Some articles published before 1987 were included because of their relevance to the topic. SUMMARY OF THE FINDINGS: There are no clinical studies comparing the efficacy of intradermal and percutaneous BCG. Percutaneous BCG causes a weaker reaction, however it is also less efficient in stimulating gamma-interferon production by Th1-lymphocytes, which is considered as the best marker of the anti-tuberculin immune response. CONCLUSIONS: In vivo and in vitro studies suggest a better immune response with intradermal BCG. The intradermal method should be recommended for BCG administration.
Keywords : BCG vaccine [administration]; adverse effects; efficacy; tuberculosis [prevention and control].