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Jornal de Pediatria
On-line version ISSN 1678-4782
MERCADANTE, Marcos T.; ROSARIO-CAMPOS, Maria C.; QUARANTINI, Lucas C. and SATO, Fabio P.. The neurobiological bases of obsessive-compulsive disorder and Tourette syndrome. J. Pediatr. (Rio J.) [online]. 2004, vol.80, n.2, suppl., pp. 35-44. ISSN 1678-4782. http://dx.doi.org/10.1590/S0021-75572004000300006.
OBJECTIVE: To describe and discuss evidence-based articles on the neurobiology of obsessive-compulsive disorder and Tourette syndrome. SOURCES OF DATA: A review of the most relevant papers on the phenomenology, neuroanatomy, neuroimaging, genetic and immunological aspects of these two disorders was performed. SUMMARY OF THE FINDINGS: Ritualistic behaviors and repetitive thoughts have been extensively studied in the last years. The definitions of obsessive-compulsive disorder and Tourette syndrome emphasize the existence of a continuum of symptoms, with high prevalence in the general population. Neurobiological findings have implicated genetic and immunological factors in the etiology of these two disorders. CONCLUSIONS: Advances in neuroscience triggered genetic and immunological research studies, allowing new perspectives on the treatment of obsessive-compulsive disorder and Tourette syndrome patients.
Keywords : Obsessive-compulsive disorder; Tourette syndrome; Tic disorders; Neuroscience.