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Jornal de Pediatria

On-line version ISSN 1678-4782


DI NUZZO, Dayana V. P.  and  FONSECA, Silvana F.. Sickle cell disease and infection. J. Pediatr. (Rio J.) [online]. 2004, vol.80, n.5, pp. 347-354. ISSN 1678-4782.

OBJECTIVE: To discuss the high prevalence of sickle cell disease in our environment and the increased morbidity and mortality as a result of infection associated with this condition. SOURCES OF DATA: Review of MEDLINE from 1986 to 2003. We found around 600 references about the subject. Thirty-five journal articles were reviewed, in addition to chapters in two text books. SUMMARY OF THE FINDINGS: We discuss general information concerning sickle cell disease as well as a few topics about the most frequently observed infections in these patients. Drug prophylaxis and immunizations are also covered. CONCLUSIONS: This review hopes to provide the pediatric community with information concerning the association between sickle cell disease and infections, so as to minimize the occurrence of complications.

Keywords : Sickle cell disease; infection; penicillin; immunization.

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