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Jornal de Pediatria
On-line version ISSN 1678-4782
PROCIANOY, Renato S. and SILVEIRA, Rita C.. The role of sample collection timing on interleukin-6 levels in early-onset neonatal sepsis . J. Pediatr. (Rio J.) [online]. 2004, vol.80, n.5, pp.407-410. ISSN 1678-4782. http://dx.doi.org/10.1590/S0021-75572004000600012.
OBJECTIVE: To assess different perinatal findings and sample collection timing in newborns with early-onset sepsis comparing those with low IL-6 levels to the ones with high levels. METHODS: Eighty-five newborn infants, with clinical signs of sepsis and/or positive blood cultures, had plasma IL-6 collected in the initial evaluation for early-onset sepsis in the first 96 hours of life. They were classified in two groups according to their plasma IL-6 levels: higher, and equal to or lower than IL-6 median value for the whole septic group RESULTS: Median IL-6 for the whole group was 89 pg/ml. High and low level groups were formed by 42 and 43 newborns respectively. There were no differences between the two groups regarding gestational ages, birth weights, cesarean-section proportion, Apgar scores, number of neonates with maternal risk factors for infection, number of maternal intrapartum antibiotic therapy, and number of positive blood cultures. Median plasma IL-6 in the high level group was 287 pg/ml, and in the low level group 46 pg/ml (p < 0.001). Median sample timing was 17.5 hours of life for the high level group and 36 hours of life for the low level group (p < 0.001). There was a significant negative correlation coefficient between IL-6 levels and sample collection timing. CONCLUSION: Sample collection timing is an important factor for detection of high plasma IL-6 level in newborn infants with early-onset sepsis.
Keywords : Cytokines; neonatal sepsis; infection; interleukin-6.