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Jornal de Pediatria
On-line version ISSN 1678-4782
AREND, Elisete E.; FISCHER, Gilberto B.; DEBIASI, Márcio and SCHMID, Helena. Inhaled corticosteroid treatment and growth of asthmatic children seen at outpatient clinics. J. Pediatr. (Rio J.) [online]. 2006, vol.82, n.3, pp. 197-203. ISSN 1678-4782. http://dx.doi.org/10.2223/JPED.1486.
OBJECTIVE: To ascertain the effect of inhaled corticosteroid use on gain in height and weight of asthmatic pediatric outpatients. METHODS: A one-year prospective cohort study was carried out with 124 asthmatic children aged 3 to 16 years who were prescribed inhaled corticosteroids for at least 12 months, evaluating z-scores for height/age, weight/age, body mass index and parental target height for current age. Exclusion criteria were: birth weight less than 2,500 g, malnutrition, chronic diseases and systemic corticoid use for more than 7 consecutive days. RESULTS: The mean ± standard deviation for z-scores for initial and final height/age were 0.06±1.2 and 0.01±1.2, (95%CI 0.05-0.11), respectively; for initial and final weight/age z-scores they were 0.6±1.5 and 0.5±1.5 (95%CI 1.84-6.6), respectively. These figures did not differ significantly (p = 0.199 and p = 0.808). There was also no loss in stature when children were stratified into well and poorly controlled asthma or into pubescent and non-pubescent groups. CONCLUSIONS: In comparison with the NCHS (National Center for Health Statistics) growth curves, there was no compromise to the height or body weight of children/adolescents using inhaled corticosteroids for more than 1 year at the doses recommended for asthma prevention.
Keywords : Corticosteroids; asthma; growth; children; adolescents.