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Jornal de Pediatria
On-line version ISSN 1678-4782
ANDRADE, Cláudia R. de; CAMARGOS, Paulo Augusto M.; IBIAPINA, Cássio da C. and LASMAR, Laura Maria de L. B. F.. Basal cortisol in asthmatics on two different doses of fluticasone propionate. J. Pediatr. (Rio J.) [online]. 2008, vol.84, n.4, pp.373-376. ISSN 1678-4782. http://dx.doi.org/10.1590/S0021-75572008000400014.
OBJECTIVES: To evaluate basal plasma cortisol in persistent asthmatics on inhaled fluticasone propionate 200 mcg/day and 300 mcg/day. METHODS: Asthma diagnosis and classification was based on Global Initiative for Asthma recommendations. Patients aged 11 years old or less received fluticasone propionate 200 mcg/day and those older than 11 years received 300 mcg/day. After 10 weeks of treatment, plasma cortisol levels were monitored to evaluate the hypothalamic-pituitary-adrenal axis. RESULTS: Forty-one patients (65.9% males) aged 6 to 18 years old were evaluated. No statistical differences were found between plasma cortisol levels in patients who received 200 mcg/day (n = 13) and those who received 300 mcg/day (n = 28). CONCLUSIONS: Our results show that low and moderate doses of fluticasone propionate do not cause adrenal suppression.
Keywords : Asthma; cortisol; corticosteroids.