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Jornal de Pediatria

Print version ISSN 0021-7557


CORREA, Fernanda Ferreira et al. Open challenge for the diagnosis of cow's milk protein allergy. J. Pediatr. (Rio J.) [online]. 2010, vol.86, n.2, pp.163-163. ISSN 0021-7557.

OBJECTIVES: To report the results of open challenge tests performed in children fed with cow's milk-free diet. DESCRIPTIONS: Cross-sectional study evaluating cow's milk open challenge performed under supervision in a hospital setting during 2.5 hours and ambulatory follow-up for 30 days when no immediate reaction occurred. One hundred and twenty-one patients were included, with ages between 4 and 95 months. Cow's milk open challenge tests were positive in 28 patients (23.1%). A clinical manifestation of cow's milk allergy different from the one presented at diagnosis occurred in 12 (24.9%) patients with positive challenge. Positive challenge was more frequent (p = 0.042) in patients fed with extensively hydrolyzed formulae or amino acid-based formulae (30.3%) when compared to those fed with other exclusion diets (14.5%). CONCLUSION: Open challenge allowed the interruption of exclusion diet in a significant proportion of the patients.

Keywords : Milk allergy [diagnosis]; milk protein; cow's milk; diagnosis; immunologic tolerance.

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