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IL-6, TNF-α, IL-10, and nutritional status in pediatric patients with biliary atresia Please cite this article as: Wilasco MI, Uribe-Cruz C, Santetti D, Fries GR, Dornelles CT, Silveira TR. IL-6, TNF-α, IL-10, and nutritional status in pediatric patients with biliary atresia. J Pediatr (Rio J). 2017;93:517–24. ,☆☆ ☆☆ Study conducted at Universidade Federal do Rio Grande do Sul, Faculdade de Medicina, Programa de Pós-graduação em Saúde da Criança e do Adolescente, Porto Alegre, RS, Brazil.

Abstract

Objectives:

The objective of the present study is to evaluate whether IL-6, TNF-α, IL-10 are associated with nutritional status in patients with cirrhosis secondary to biliary atresia and compare to healthy controls.

Methods:

The parameters used for nutritional assessment were the standard deviation scores of height-for-age and of triceps skinfold thickness-for-age. The severity of cirrhosis was evaluated using the Child–Pugh score and PELD/MELD. Serum cytokines were measured using Cytometric Bead Array flow cytometry.

Results:

IL-6, TNF-α, and IL-10 were significantly higher in the cirrhosis group when compared with the control group (2.4 vs. 0.24 (p < 0.001), 0.21 vs. 0.14 (p = 0.007), and 0.65 vs. 0.36 (p = 0.004), respectively. IL-6 and IL-10 were positively correlated with disease severity (0.450 [p = 0.001] and 0.410; [p = 0.002], respectively). TNF-α did not show a significant correlation with disease severity (0.100; p = 0.478). Regarding nutritional evaluation, IL-6 was negatively correlated with the standard deviation score of height-for-age (−0.493; p < 0.001) and of triceps skinfold thickness-for-age (−0.503; p < 0.001), respectively. IL-10 exhibited a negative correlation with the standard deviation score of height-for-age (−0.476; p < 0.001) and the standard deviation score of triceps skinfold thickness-for-age (−0.388; p = 0.004). TNF-α did not show any significance in both anthropometric parameters (−0.083 (p = 0.555) and −0.161 (p = 0.253).

Conclusion:

The authors suggest that, in patients with cirrhosis secondary to biliary atresia, IL-6 could be used as a possible supporting biomarker of deficient nutritional status and elevated IL-10 levels could be used as a possible early-stage supporting biomarker of deteriorating nutritional status.

KEYWORDS
IL-6; TNF-α; IL-10; Nutritional status; Cirrhosis; Biliary atresia

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