Gestational weight gain
|
>12 kg |
≥4000 g |
|
|
<0.001 |
SE |
Lizo et al.3232 Lizo CL, Azevedo-Lizo Z, Aronson E, Segre CA. Relação entre ganho de peso materno e peso do recém-nascido. J Pediatr (Rio J). 1998;74:114-8.
|
Excess |
≥4000 g |
RR = 2.80 (0.80-7.70) |
|
0.070 |
SE |
Oliveira et al.2424 Oliveira LC, Pacheco AH, Rodrigues PL, Schlussel MM, Spyrides MH, Kac G. Factors accountable for macrosomia incidence in a study with mothers and progeny attended at a Basic Unity of Health in Rio de Janeiro, Brazil. Rev Bras Ginecol Obstet. 2008;30:486-93.
|
Excess |
≥4000 g |
PR = 6.90 (2.90-16.90) |
|
|
NE |
Amorim et al.4343 Amorim MM, Leite DF, Gadelha TG, Muniz AG, Mela AS, Rocha AM. Risk factors for macrosomia in newborns at a school-maternity in northeast of Brazil. Rev Bras Ginecol Obstet. 2009;31:241-8.
|
Excess |
≥4000 g |
|
|
<0.001 |
NE |
Rodrigues et al.4444 Rodrigues PL, Oliveira CL, Brito AD, Kac G. Determinant factors of insufficient and excess gestational weight gain and maternal-child adverse outcomes. Nutrition. 2010;26:617-23.
|
9-12 kg |
≥4000 g |
OR = 1.30 (0.70-2.40) |
|
0.030 |
S |
Gonçalves et al.4545 Gonçalves CV, Mendoza-Sassi RA, Cesar JA, Castro NB, Bortolomedi AP. Body mass index and gestational weight gain as factors predicting complications and pregnancy outcome. Rev Bras Ginecol Obstet. 2012;34:304-9.
|
13-16 kg |
≥4000 g |
OR = 1.10 (0.60-2.30) |
|
0.030 |
S |
Gonçalves et al.4545 Gonçalves CV, Mendoza-Sassi RA, Cesar JA, Castro NB, Bortolomedi AP. Body mass index and gestational weight gain as factors predicting complications and pregnancy outcome. Rev Bras Ginecol Obstet. 2012;34:304-9.
|
≥17 kg |
≥4000 g |
OR = 1.70 (0.80-3.40) |
|
0.030 |
S |
Gonçalves et al.4545 Gonçalves CV, Mendoza-Sassi RA, Cesar JA, Castro NB, Bortolomedi AP. Body mass index and gestational weight gain as factors predicting complications and pregnancy outcome. Rev Bras Ginecol Obstet. 2012;34:304-9.
|
Excess |
≥4000 g |
|
|
0.010 |
MW |
Costa et al.4646 Costa BM, Paulinelli RR, Barbosa MA. Association between maternal and fetal weight gain: cohort study. Sao Paulo Med J. 2012;130:242-7.
|
Excess |
≥4000 g |
|
|
0.044 |
NE |
Silva and Macedo4040 Silva DG, Macedo NB. Association between gestational weight gain and pregnancy outcome. Sci Med. 2014;24:229-36.
|
Excess |
≥4000 g |
OR = 1.75 (0.76-4.04) |
|
0.260 |
SE |
Fonseca et al.4747 da Fonseca MR, Laurenti R, Marin CR, Traldi MC. Ganho de peso gestacional e peso ao nascer do concepto: estudo transversal na região de Jundiaí, São Paulo, Brasil. Cienc Saude Colet. 2014;19:1401-7.
|
>16 kg |
>90th percentile |
OR = 1.79 (1.23-2.60) |
|
0.020 |
SE |
Kerche et al.4242 Kerche LT, Abbade JF, Costa RA, Rudge MV. Calderon IdM. Fatores de risco para macrossomia fetal em gestações complicadas por diabete ou por hiperglicemia diária. Rev Bras Ginecol Obstet. 2005;27:580-7.
|
Excess |
>90th percentile |
RR = 4.70 (1.60-14.00) |
|
0.009 |
NE |
Santos et al.3434 Santos EM, Amorim LP, Costa OL, Oliveira N, Guimarães AC. Profile of gestational and metabolic risk in the prenatal care service of a public maternity in the Brazilian Northeast. Rev Bras Ginecol Obstet. 2012;34:102-6.
|
Excess 2nd trimester |
>90th percentile |
RR = 1.64 (1.16-2.31) |
|
|
S, SE, N, NE |
Drehmer et al.4848 Drehmer M, Duncan BB, Kac G, Schmidt MI. Association of second and third trimester weight gain in pregnancy with maternal and fetal outcomes. PLOS ONE. 2013;8:e54704.
|
Excess |
>90th percentile |
RR = 2.12 (1.55-2.89) |
|
|
S, SE, N, NE |
Drehmer et al.4848 Drehmer M, Duncan BB, Kac G, Schmidt MI. Association of second and third trimester weight gain in pregnancy with maternal and fetal outcomes. PLOS ONE. 2013;8:e54704.
|
Excess |
>90th percentile |
OR = 0.95 (0.48-1.86) |
Smoking, parity, number of prenatal consultations, nutritional assistance |
0.891 |
SE |
Padilha et al.5050 Padilha C, Barros DC, Campos AB, Ayeta AC, Queiroz JA, Saunders C. Performance of an anthropometric assessment method as a predictor of low birthweight and being small for gestational age. J Hum Nutr Diet. 2014;28:292-9.
|
Excess |
>90th percentile |
PR = 2.26 (1.21-4.24) |
Maternal age, family income, pre-gestational BMI, GWG, cholesterol |
0.011 |
SE |
Castro et al.4949 Castro MB, Farias DR, Lepsch J, Mendes RH, Ferreira AA, Kac G. High cholesterol dietary intake during pregnancy is associated with large for gestational age in a sample of low-income women of Rio de Janeiro, Brazil. Matern Child Nutr. 2016;13:580-7.
|
Excess |
>90th percentile |
|
|
0.013 |
S |
Kroll et al.2828 Kroll C, Mastroeni SS, Veugelers PJ, Mastroeni MF. Association of ADIPOQ, LEP, and FTO gene polymorphisms with large for gestational age infants. Am J Hum Biol. 2017;29:e22893.
|
Excess |
>90th percentile |
OR = 2.11 (1.27-3.15) |
Schooling, family income, smoking during pregnancy, age of first child, pre-gestational BMI, glycated hemoglobin |
|
S |
Mastroeni et al.1313 Mastroeni MF, Czarnobay SA, Kroll C, Figueirêdo KB, Mastroeni SS, Silva JC, et al. The independent importance of pre-pregnancy weight and gestational weight gain for the prevention of large-for gestational age Brazilian newborns. Matern Child Health J. 2017;21:705-14.
|
Pre-gestational BMI
|
Pre-obese |
>90th percentile |
OR = 1.61 (1.30-2.00) |
|
|
S, SE, N, NE |
Nucci et al.5151 Nucci LB, Schmidt MI, Duncan BB, Fuchs SC, Fleck ET, Britto MM. Nutritional status of pregnant women: prevalence and associated pregnancy outcomes. Rev Saude Publica. 2001;35:502-7.
|
Obese |
>90th percentile |
OR = 1.53 (1.08-2.17) |
|
|
S, SE, N, NE |
Nucci et al.5151 Nucci LB, Schmidt MI, Duncan BB, Fuchs SC, Fleck ET, Britto MM. Nutritional status of pregnant women: prevalence and associated pregnancy outcomes. Rev Saude Publica. 2001;35:502-7.
|
≥25 kg/m2
|
>90th percentile |
OR = 1.83 (1.27-2.64) |
|
0.003 |
SE |
Kerche et al.4242 Kerche LT, Abbade JF, Costa RA, Rudge MV. Calderon IdM. Fatores de risco para macrossomia fetal em gestações complicadas por diabete ou por hiperglicemia diária. Rev Bras Ginecol Obstet. 2005;27:580-7.
|
Overweight/obesity |
>90th percentile |
|
|
0.020 |
SE |
Nomura et al.4141 Nomura RM, Paiva LV, Costa VN, Liao AW, Zugaib M. Influência do estado nutricional materno, ganho de peso e consumo energético sobre o crescimento fetal, em gestações de alto risco. Rev Bras Ginecol Obstet. 2012;34:107-12.
|
≥25 kg/m2
|
>90th percentile |
PR = 1.88 (1.05-3.36) |
|
0.033 |
SE |
Castro et al.4949 Castro MB, Farias DR, Lepsch J, Mendes RH, Ferreira AA, Kac G. High cholesterol dietary intake during pregnancy is associated with large for gestational age in a sample of low-income women of Rio de Janeiro, Brazil. Matern Child Nutr. 2016;13:580-7.
|
Obesity |
>90th percentile |
|
|
0.021 |
SE |
Vernini et al.5252 Vernini JM, Moreli JB, Magalhães CG, Costa RA, Rudge MV, Calderon IM. Maternal and fetal outcomes in pregnancies complicated by overweight and obesity. Reprod Health. 2016;13:100.
|
<25 kg/m2
|
>90th percentile |
|
|
0.677 |
S |
Kroll et al.2828 Kroll C, Mastroeni SS, Veugelers PJ, Mastroeni MF. Association of ADIPOQ, LEP, and FTO gene polymorphisms with large for gestational age infants. Am J Hum Biol. 2017;29:e22893.
|
Overweight |
>90th percentile |
OR = 1.00 (0.54-1.79) |
Schooling, family income, smoking during pregnancy, age of first child, GWG, glycated hemoglobin |
|
S |
Mastroeni et al.1313 Mastroeni MF, Czarnobay SA, Kroll C, Figueirêdo KB, Mastroeni SS, Silva JC, et al. The independent importance of pre-pregnancy weight and gestational weight gain for the prevention of large-for gestational age Brazilian newborns. Matern Child Health J. 2017;21:705-14.
|
Obesity |
>90th percentile |
OR = 1.15 (0.56-2.36) |
Schooling, family income, smoking during pregnancy, age of first child, GWG, glycated hemoglobin |
|
S |
Mastroeni et al.1313 Mastroeni MF, Czarnobay SA, Kroll C, Figueirêdo KB, Mastroeni SS, Silva JC, et al. The independent importance of pre-pregnancy weight and gestational weight gain for the prevention of large-for gestational age Brazilian newborns. Matern Child Health J. 2017;21:705-14.
|
≥25 kg/m2
|
>90th percentile |
|
|
0.042 |
SE |
Farias et al.1414 Farias DR, Poston L, Franco-Sena AB, Silva AA, Pinto T, Oliveira LC, et al. Maternal lipids and leptin concentrations are associated with large-for-gestational-age births: a prospective cohort study. Sci Rep. 2017;7:84.
|
Overweight/obesity |
≥4000 g |
RR = 3.70 (1.80-9.20) |
|
0.010 |
SE |
Oliveira et al.2424 Oliveira LC, Pacheco AH, Rodrigues PL, Schlussel MM, Spyrides MH, Kac G. Factors accountable for macrosomia incidence in a study with mothers and progeny attended at a Basic Unity of Health in Rio de Janeiro, Brazil. Rev Bras Ginecol Obstet. 2008;30:486-93.
|
Overweight/obesity |
≥4000 g |
PR = 2.80 (1.00-7.80) |
|
|
NE |
Amorim et al.4343 Amorim MM, Leite DF, Gadelha TG, Muniz AG, Mela AS, Rocha AM. Risk factors for macrosomia in newborns at a school-maternity in northeast of Brazil. Rev Bras Ginecol Obstet. 2009;31:241-8.
|
Overweight |
≥4000 g |
OR = 3.40 (0.40-26.10) |
|
0.001 |
S |
Gonçalves et al.4545 Gonçalves CV, Mendoza-Sassi RA, Cesar JA, Castro NB, Bortolomedi AP. Body mass index and gestational weight gain as factors predicting complications and pregnancy outcome. Rev Bras Ginecol Obstet. 2012;34:304-9.
|
Obesity |
≥4000 g |
OR = 6.70 (0.90-52.50) |
|
0.001 |
S |
Gonçalves et al.4545 Gonçalves CV, Mendoza-Sassi RA, Cesar JA, Castro NB, Bortolomedi AP. Body mass index and gestational weight gain as factors predicting complications and pregnancy outcome. Rev Bras Ginecol Obstet. 2012;34:304-9.
|
Obesity |
≥4000 g |
|
|
0.037 |
SE |
Vernini et al.5252 Vernini JM, Moreli JB, Magalhães CG, Costa RA, Rudge MV, Calderon IM. Maternal and fetal outcomes in pregnancies complicated by overweight and obesity. Reprod Health. 2016;13:100.
|
Obesity |
≥4000 g |
OR = 1.20 (1.44-2.32) |
Hyperglycemic Disorder |
<0.010 |
S |
Madi et al.2525 Madi SR, Garcia RM, Souza VC, Rombaldi RL, Araujo BF, Madi JM. Effect of obesity on gestational and perinatal outcomes. Rev Bras Ginecol Obstet. 2017;39:330-6.
|
BMI ≥25
kg/m
2
on the last consultation
|
≥4000 g |
PR = 4.90 (2.00-12.50) |
|
|
NE |
Amorim et al.4343 Amorim MM, Leite DF, Gadelha TG, Muniz AG, Mela AS, Rocha AM. Risk factors for macrosomia in newborns at a school-maternity in northeast of Brazil. Rev Bras Ginecol Obstet. 2009;31:241-8.
|
BMI during pregnancy
|
≥25 kg/m2
|
>90th percentile |
RR = 1.90 (1.20-3.00) |
|
|
SE |
Rehder et al.5353 Rehder PM, Pereira BG, Silva JL. Resultados gestacionais e neonatais em mulheres com rastreamento positivo para diabetes mellitus e teste oral de tolerância à glicose - 100 g normal. Rev Bras Ginecol Obstet. 2011;33:81-6.
|
Overweight/obesity |
>90th percentile |
|
|
0.030 |
SE |
Carniello et al.5454 Carniello LV, Guarnieri GU, Venâncio JA, Cruz FL, Rodrigues EC, Augusto CC, et al. Resultado perinatal dos recém-nascidos em relação ao índice de massa corpórea (IMC) materno no momento do parto em um hospital terciário da Baixada Santista. Rev UNILUS Ensino Pesqui. 2015;12:79-85.
|
Overweight/obesity |
>90th percentile |
|
|
0.340 |
S |
Leal et al.5757 Leal RC, Santos CN, Lima MJ, Moura SK, Pedrosa AO, Costa AC. Maternal-perinatal complications in high risk pregnancy. J Nurs UFPE on line. 2017;11:1641-9.
|
≥25 kg/m2
|
>4000 g |
RR = 2.00 (0.90-4.00) |
|
|
SE |
Rehder et al.5353 Rehder PM, Pereira BG, Silva JL. Resultados gestacionais e neonatais em mulheres com rastreamento positivo para diabetes mellitus e teste oral de tolerância à glicose - 100 g normal. Rev Bras Ginecol Obstet. 2011;33:81-6.
|
Obesity at the moment of delivery |
>90th percentile |
OR = 3.60 (1.10-11.70) |
Smoking, diagnosis of arterial hypertension, DM, GWG, pre-gestational BMI, BMI at the end of pregnancy, classification of maternal nutritional status by pre-gestational BMI and at the end of pregnancy |
0.040 |
SE |
Nomura et al.4141 Nomura RM, Paiva LV, Costa VN, Liao AW, Zugaib M. Influência do estado nutricional materno, ganho de peso e consumo energético sobre o crescimento fetal, em gestações de alto risco. Rev Bras Ginecol Obstet. 2012;34:107-12.
|
BMI ≥25
kg/m
2
at the beginning of pregnancy
|
≥4000 g |
|
|
<0.010 |
SE |
Fonseca et al.4747 da Fonseca MR, Laurenti R, Marin CR, Traldi MC. Ganho de peso gestacional e peso ao nascer do concepto: estudo transversal na região de Jundiaí, São Paulo, Brasil. Cienc Saude Colet. 2014;19:1401-7.
|
Association of pre-gestational BMI and GWG
|
Low/normal weight and excess GWG |
>90th percentile |
OR = 2.08 (1.10-3.95) |
Schooling, family income, smoking during pregnancy, age of first child, glycated hemoglobin |
|
S |
Mastroeni et al.1313 Mastroeni MF, Czarnobay SA, Kroll C, Figueirêdo KB, Mastroeni SS, Silva JC, et al. The independent importance of pre-pregnancy weight and gestational weight gain for the prevention of large-for gestational age Brazilian newborns. Matern Child Health J. 2017;21:705-14.
|
Overweight and appropriate GWG |
>90th percentile |
OR = 0.46 (0.13-1.64) |
Schooling, family income, smoking during pregnancy, age of first child, glycated hemoglobin |
|
S |
Mastroeni et al.1313 Mastroeni MF, Czarnobay SA, Kroll C, Figueirêdo KB, Mastroeni SS, Silva JC, et al. The independent importance of pre-pregnancy weight and gestational weight gain for the prevention of large-for gestational age Brazilian newborns. Matern Child Health J. 2017;21:705-14.
|
Overweight and excess GWG |
>90th percentile |
OR = 2.54 (1.27-5.10) |
Schooling, family income, smoking during pregnancy, age of first child, glycated hemoglobin |
|
S |
Mastroeni et al.1313 Mastroeni MF, Czarnobay SA, Kroll C, Figueirêdo KB, Mastroeni SS, Silva JC, et al. The independent importance of pre-pregnancy weight and gestational weight gain for the prevention of large-for gestational age Brazilian newborns. Matern Child Health J. 2017;21:705-14.
|
Obesity and appropriate GWG |
>90th percentile |
OR = 1.94 (0.72-5.25) |
Schooling, family income, smoking during pregnancy, age of first child, glycated hemoglobin |
|
S |
Mastroeni et al.1313 Mastroeni MF, Czarnobay SA, Kroll C, Figueirêdo KB, Mastroeni SS, Silva JC, et al. The independent importance of pre-pregnancy weight and gestational weight gain for the prevention of large-for gestational age Brazilian newborns. Matern Child Health J. 2017;21:705-14.
|
Obesity and excess GWG |
>90th percentile |
OR = 1.54 (0.58-4.08) |
Schooling, family income, smoking during pregnancy, age of first child, glycated hemoglobin |
|
S |
Mastroeni et al.1313 Mastroeni MF, Czarnobay SA, Kroll C, Figueirêdo KB, Mastroeni SS, Silva JC, et al. The independent importance of pre-pregnancy weight and gestational weight gain for the prevention of large-for gestational age Brazilian newborns. Matern Child Health J. 2017;21:705-14.
|
Diabetes mellitus
|
Present |
>90th percentile |
|
|
0.050 |
SE |
Kerche et al.4242 Kerche LT, Abbade JF, Costa RA, Rudge MV. Calderon IdM. Fatores de risco para macrossomia fetal em gestações complicadas por diabete ou por hiperglicemia diária. Rev Bras Ginecol Obstet. 2005;27:580-7.
|
Present |
>90th percentile |
OR = 20.2 (5.30-76.80) |
Smoking, diagnosis of arterial hypertension, DM, GWG, pre-gestational BMI, BMI at the end of pregnancy, maternal nutritional status classification by pre-gestational BMI and at the end of the pregnancy |
<0.001 |
SE |
Nomura et al.4141 Nomura RM, Paiva LV, Costa VN, Liao AW, Zugaib M. Influência do estado nutricional materno, ganho de peso e consumo energético sobre o crescimento fetal, em gestações de alto risco. Rev Bras Ginecol Obstet. 2012;34:107-12.
|
Present |
>90th percentile |
|
|
0.580 |
S |
Kroll et al.2828 Kroll C, Mastroeni SS, Veugelers PJ, Mastroeni MF. Association of ADIPOQ, LEP, and FTO gene polymorphisms with large for gestational age infants. Am J Hum Biol. 2017;29:e22893.
|
Present |
>90th percentile |
OR = 1.08 (0.47-2.51) |
|
|
S |
Mastroeni et al.1313 Mastroeni MF, Czarnobay SA, Kroll C, Figueirêdo KB, Mastroeni SS, Silva JC, et al. The independent importance of pre-pregnancy weight and gestational weight gain for the prevention of large-for gestational age Brazilian newborns. Matern Child Health J. 2017;21:705-14.
|
Present |
≥4000 g |
OR = 4.20 (2.70-6.40) |
|
<0.050 |
S |
Madi et al.2525 Madi SR, Garcia RM, Souza VC, Rombaldi RL, Araujo BF, Madi JM. Effect of obesity on gestational and perinatal outcomes. Rev Bras Ginecol Obstet. 2017;39:330-6.
|
Present |
≥4000 g |
PR = 8.90 (4.10-19.40) |
|
|
SE |
Amorim et al.4343 Amorim MM, Leite DF, Gadelha TG, Muniz AG, Mela AS, Rocha AM. Risk factors for macrosomia in newborns at a school-maternity in northeast of Brazil. Rev Bras Ginecol Obstet. 2009;31:241-8.
|
Presence of GDM
|
|
≥90th percentile |
ADA, RR = 1.29 (0.73-2.18) |
Ethnicity, maternal height, pre-gestational BMI, GWG, and NB gender. |
|
S, SE, N, NE |
Schmidt et al.2626 Schmidt MI, Duncan BB, Reichelt AJ, Branchtein L, Matos MC, Costa e Forti A, et al. Gestational diabetes mellitus diagnosed with a 2-h 75-g oral glucose tolerance test and adverse pregnancy outcomes. Diabetes Care. 2001;24:1151-5.
|
|
≥90th percentile |
WHO, RR = 1.45 (1.06-1.95) |
Ethnicity, maternal height, pre-gestational BMI, GWG, and NB gender. |
|
S, SE, N, NE |
Schmidt et al.2626 Schmidt MI, Duncan BB, Reichelt AJ, Branchtein L, Matos MC, Costa e Forti A, et al. Gestational diabetes mellitus diagnosed with a 2-h 75-g oral glucose tolerance test and adverse pregnancy outcomes. Diabetes Care. 2001;24:1151-5.
|
|
≥90th percentile |
|
|
0.100 |
S |
Leal et al.5757 Leal RC, Santos CN, Lima MJ, Moura SK, Pedrosa AO, Costa AC. Maternal-perinatal complications in high risk pregnancy. J Nurs UFPE on line. 2017;11:1641-9.
|
|
>90th percentile |
|
|
0.050 |
SE |
Kerche et al.4242 Kerche LT, Abbade JF, Costa RA, Rudge MV. Calderon IdM. Fatores de risco para macrossomia fetal em gestações complicadas por diabete ou por hiperglicemia diária. Rev Bras Ginecol Obstet. 2005;27:580-7.
|
|
≥90th percentile |
IADPSG, RR = 1.40 (1.15-1.70) |
|
|
S, SE, N, NE |
Trujillo et al.5656 Trujillo J, Vigo A, Duncan BB, Falavigna M, Wendland EM, Campos MA, et al. Impact of the International Association of Diabetes and Pregnancy Study Groups criteria for gestational diabetes. Diabetes Res Clin Pract. 2015;108:288-95.
|
|
≥90th percentile |
WHO, RR = 1.67 (1.30-2.15) |
|
|
S, SE, N, NE |
Trujillo et al.5656 Trujillo J, Vigo A, Duncan BB, Falavigna M, Wendland EM, Campos MA, et al. Impact of the International Association of Diabetes and Pregnancy Study Groups criteria for gestational diabetes. Diabetes Res Clin Pract. 2015;108:288-95.
|
|
≥90th percentile |
ADA, RR = 1.50 (0.95-2.34) |
|
|
S, SE, N, NE |
Trujillo et al.5656 Trujillo J, Vigo A, Duncan BB, Falavigna M, Wendland EM, Campos MA, et al. Impact of the International Association of Diabetes and Pregnancy Study Groups criteria for gestational diabetes. Diabetes Res Clin Pract. 2015;108:288-95.
|
|
≥4000 g |
PR = 12.0 (6.0-24.2) |
|
|
NE |
Amorim et al.4343 Amorim MM, Leite DF, Gadelha TG, Muniz AG, Mela AS, Rocha AM. Risk factors for macrosomia in newborns at a school-maternity in northeast of Brazil. Rev Bras Ginecol Obstet. 2009;31:241-8.
|
History of DM
|
Any |
>90th percentile |
|
|
0.262 |
SE |
Kerche et al.4242 Kerche LT, Abbade JF, Costa RA, Rudge MV. Calderon IdM. Fatores de risco para macrossomia fetal em gestações complicadas por diabete ou por hiperglicemia diária. Rev Bras Ginecol Obstet. 2005;27:580-7.
|
Family |
>90th percentile |
|
|
0.073 |
SE |
Kerche et al.4242 Kerche LT, Abbade JF, Costa RA, Rudge MV. Calderon IdM. Fatores de risco para macrossomia fetal em gestações complicadas por diabete ou por hiperglicemia diária. Rev Bras Ginecol Obstet. 2005;27:580-7.
|
Personal |
>90th percentile |
OR = 1.56 (1.05-2.31) |
|
0.003 |
SE |
Kerche et al.4242 Kerche LT, Abbade JF, Costa RA, Rudge MV. Calderon IdM. Fatores de risco para macrossomia fetal em gestações complicadas por diabete ou por hiperglicemia diária. Rev Bras Ginecol Obstet. 2005;27:580-7.
|
Obstetric |
>90th percentile |
|
|
<0.001 |
SE |
Kerche et al.4242 Kerche LT, Abbade JF, Costa RA, Rudge MV. Calderon IdM. Fatores de risco para macrossomia fetal em gestações complicadas por diabete ou por hiperglicemia diária. Rev Bras Ginecol Obstet. 2005;27:580-7.
|
History of GDM
|
|
>90th percentile |
RR = 0.40 (0.10-2.60) |
|
|
SE |
Rehder et al.5353 Rehder PM, Pereira BG, Silva JL. Resultados gestacionais e neonatais em mulheres com rastreamento positivo para diabetes mellitus e teste oral de tolerância à glicose - 100 g normal. Rev Bras Ginecol Obstet. 2011;33:81-6.
|
|
>4000 g |
RR = 0.90 (0.10-6.60) |
|
|
SE |
Rehder et al.5353 Rehder PM, Pereira BG, Silva JL. Resultados gestacionais e neonatais em mulheres com rastreamento positivo para diabetes mellitus e teste oral de tolerância à glicose - 100 g normal. Rev Bras Ginecol Obstet. 2011;33:81-6.
|
Groups of Rudge IB, IIA + IIB |
>90th percentile |
|
|
0.030 |
SE |
Kerche et al.4242 Kerche LT, Abbade JF, Costa RA, Rudge MV. Calderon IdM. Fatores de risco para macrossomia fetal em gestações complicadas por diabete ou por hiperglicemia diária. Rev Bras Ginecol Obstet. 2005;27:580-7.
|
Total blood glucose mean ≥120 mg/dL |
>90th percentile |
OR = 1.78 (1.13-2.80) |
|
0.000 |
SE |
Kerche et al.4242 Kerche LT, Abbade JF, Costa RA, Rudge MV. Calderon IdM. Fatores de risco para macrossomia fetal em gestações complicadas por diabete ou por hiperglicemia diária. Rev Bras Ginecol Obstet. 2005;27:580-7.
|
Fasting blood glucose (mg/dL)
|
≥90 |
>90th percentile |
|
|
0.069 |
SE |
Kerche et al.4242 Kerche LT, Abbade JF, Costa RA, Rudge MV. Calderon IdM. Fatores de risco para macrossomia fetal em gestações complicadas por diabete ou por hiperglicemia diária. Rev Bras Ginecol Obstet. 2005;27:580-7.
|
≥90 |
>90th percentile |
RR = 1.10 (0.70-1.70) |
|
|
SE |
Rehder et al.5353 Rehder PM, Pereira BG, Silva JL. Resultados gestacionais e neonatais em mulheres com rastreamento positivo para diabetes mellitus e teste oral de tolerância à glicose - 100 g normal. Rev Bras Ginecol Obstet. 2011;33:81-6.
|
80.0-175.0 |
≥4000 g |
RR = 1.70 (0.50-4.80) |
|
0.380 |
SE |
Oliveira et al.2424 Oliveira LC, Pacheco AH, Rodrigues PL, Schlussel MM, Spyrides MH, Kac G. Factors accountable for macrosomia incidence in a study with mothers and progeny attended at a Basic Unity of Health in Rio de Janeiro, Brazil. Rev Bras Ginecol Obstet. 2008;30:486-93.
|
≥90 |
>4000 g |
RR = 0.90 (0.40-2.00) |
|
|
SE |
Rehder et al.5353 Rehder PM, Pereira BG, Silva JL. Resultados gestacionais e neonatais em mulheres com rastreamento positivo para diabetes mellitus e teste oral de tolerância à glicose - 100 g normal. Rev Bras Ginecol Obstet. 2011;33:81-6.
|
Postprandial blood glucose ≥130 mg/dL |
>90th percentile |
|
|
0.012 |
SE |
Kerche et al.4242 Kerche LT, Abbade JF, Costa RA, Rudge MV. Calderon IdM. Fatores de risco para macrossomia fetal em gestações complicadas por diabete ou por hiperglicemia diária. Rev Bras Ginecol Obstet. 2005;27:580-7.
|
Maternal age group (years)
|
>35 |
>4000 g |
RR = 1.00 (0.50-2.20) |
|
|
SE |
Rehder et al.5353 Rehder PM, Pereira BG, Silva JL. Resultados gestacionais e neonatais em mulheres com rastreamento positivo para diabetes mellitus e teste oral de tolerância à glicose - 100 g normal. Rev Bras Ginecol Obstet. 2011;33:81-6.
|
20-30 |
≥4000 g |
|
|
<0.001 |
NE |
Santos et al.5858 Santos JB, Silva JB, Silva MG, Lopes MN, Dantas PN, Lopes CM. Newborn birth weight, maternal age group and delivery method. Rev Bras Enferm. 2001;54:517-27.
|
>30 |
≥4000 g |
|
|
<0.001 |
NE |
Santos et al.5858 Santos JB, Silva JB, Silva MG, Lopes MN, Dantas PN, Lopes CM. Newborn birth weight, maternal age group and delivery method. Rev Bras Enferm. 2001;54:517-27.
|
>30 |
≥4000 g |
|
|
0.048 |
S |
Araujo and Sant'Ana5959 Araujo SG, Sant'Ana DM. Relação entre a idade materna e o peso ao nascer: um estudo da gravidez na adolescência no município de Umuarama, PR, Brasil em 2001. Ciênc Cuid Saúde. 2003;2:155-60.
|
25-29 |
>4000 g |
|
|
0.420 |
NE |
Lima and Sampaio6060 Lima GS, Sampaio HA. Influência de fatores obstétricos, socioeconômicos e nutricionais da gestante sobre o peso do recém-nascido: estudo realizado em uma maternidade em Teresina, Piauí. Rev Bras Saude Matern Infant. 2004;4:253-61.
|
30-39 |
≥4000 g |
RR = 2.40 (0.90-4.80) |
|
0.050 |
SE |
Oliveira et al.2424 Oliveira LC, Pacheco AH, Rodrigues PL, Schlussel MM, Spyrides MH, Kac G. Factors accountable for macrosomia incidence in a study with mothers and progeny attended at a Basic Unity of Health in Rio de Janeiro, Brazil. Rev Bras Ginecol Obstet. 2008;30:486-93.
|
≥25 |
≥4000 g |
PR = 1.20 (0.60-2.40) |
|
|
NE |
Amorim et al.4343 Amorim MM, Leite DF, Gadelha TG, Muniz AG, Mela AS, Rocha AM. Risk factors for macrosomia in newborns at a school-maternity in northeast of Brazil. Rev Bras Ginecol Obstet. 2009;31:241-8.
|
≥20 |
≥4000 g |
|
|
<0.001 |
SE |
Paula et al.2323 Paula HA, Salvador BC, Barbosa L, Cotta RM. Peso ao nascer e variáveis maternas no âmbito da promoção da saúde. Rev APS. 2011;14:67-74.
|
≥25 |
>90th percentile |
|
|
0.086 |
SE |
Kerche et al.4242 Kerche LT, Abbade JF, Costa RA, Rudge MV. Calderon IdM. Fatores de risco para macrossomia fetal em gestações complicadas por diabete ou por hiperglicemia diária. Rev Bras Ginecol Obstet. 2005;27:580-7.
|
>35 |
>90th percentile |
RR = 1.10 (0.70-1.80) |
|
|
SE |
Rehder et al.5353 Rehder PM, Pereira BG, Silva JL. Resultados gestacionais e neonatais em mulheres com rastreamento positivo para diabetes mellitus e teste oral de tolerância à glicose - 100 g normal. Rev Bras Ginecol Obstet. 2011;33:81-6.
|
<20 |
>90th percentile |
|
|
0.496 |
S |
Kroll et al.2828 Kroll C, Mastroeni SS, Veugelers PJ, Mastroeni MF. Association of ADIPOQ, LEP, and FTO gene polymorphisms with large for gestational age infants. Am J Hum Biol. 2017;29:e22893.
|
20-30 |
>90th percentile |
OR = 0.73 (0.39-1.35) |
|
|
S |
Mastroeni et al.1313 Mastroeni MF, Czarnobay SA, Kroll C, Figueirêdo KB, Mastroeni SS, Silva JC, et al. The independent importance of pre-pregnancy weight and gestational weight gain for the prevention of large-for gestational age Brazilian newborns. Matern Child Health J. 2017;21:705-14.
|
≥30 |
>90th percentile |
OR = 0.94 (0.47-1.85) |
|
|
S |
Mastroeni et al.1313 Mastroeni MF, Czarnobay SA, Kroll C, Figueirêdo KB, Mastroeni SS, Silva JC, et al. The independent importance of pre-pregnancy weight and gestational weight gain for the prevention of large-for gestational age Brazilian newborns. Matern Child Health J. 2017;21:705-14.
|
≤30 |
>90th percentile |
|
|
0.545 |
SE |
Farias et al.1414 Farias DR, Poston L, Franco-Sena AB, Silva AA, Pinto T, Oliveira LC, et al. Maternal lipids and leptin concentrations are associated with large-for-gestational-age births: a prospective cohort study. Sci Rep. 2017;7:84.
|
Maternal age
|
>90th percentile |
PR = 1.04 (1.0-1.09) |
|
0.073 |
SE |
Castro et al.4949 Castro MB, Farias DR, Lepsch J, Mendes RH, Ferreira AA, Kac G. High cholesterol dietary intake during pregnancy is associated with large for gestational age in a sample of low-income women of Rio de Janeiro, Brazil. Matern Child Nutr. 2016;13:580-7.
|
Parity (number of children)
|
≥2 |
≥4000 g |
|
|
0.700 |
NE |
Lima and Sampaio6060 Lima GS, Sampaio HA. Influência de fatores obstétricos, socioeconômicos e nutricionais da gestante sobre o peso do recém-nascido: estudo realizado em uma maternidade em Teresina, Piauí. Rev Bras Saude Matern Infant. 2004;4:253-61.
|
≥2 |
≥4000 g |
RR = 3.80 (1.10-9.90) |
Age, marital status, parity, NB gender, pre-gestational BMI, GWG |
0.030 |
SE |
Oliveira et al.2424 Oliveira LC, Pacheco AH, Rodrigues PL, Schlussel MM, Spyrides MH, Kac G. Factors accountable for macrosomia incidence in a study with mothers and progeny attended at a Basic Unity of Health in Rio de Janeiro, Brazil. Rev Bras Ginecol Obstet. 2008;30:486-93.
|
≥2 |
≥4000 g |
PR = 1.00 (0.50-2.00) |
|
|
NE |
Amorim et al.4343 Amorim MM, Leite DF, Gadelha TG, Muniz AG, Mela AS, Rocha AM. Risk factors for macrosomia in newborns at a school-maternity in northeast of Brazil. Rev Bras Ginecol Obstet. 2009;31:241-8.
|
≥3 |
>90th percentile |
|
|
0.136 |
SE |
Kerche et al.4242 Kerche LT, Abbade JF, Costa RA, Rudge MV. Calderon IdM. Fatores de risco para macrossomia fetal em gestações complicadas por diabete ou por hiperglicemia diária. Rev Bras Ginecol Obstet. 2005;27:580-7.
|
0 |
>90th percentile |
|
|
0.400 |
SE |
Nomura et al.4141 Nomura RM, Paiva LV, Costa VN, Liao AW, Zugaib M. Influência do estado nutricional materno, ganho de peso e consumo energético sobre o crescimento fetal, em gestações de alto risco. Rev Bras Ginecol Obstet. 2012;34:107-12.
|
≥2 |
>90th percentile |
PR = 1.41 (0.72-2.78) |
|
0.317 |
SE |
Castro et al.4949 Castro MB, Farias DR, Lepsch J, Mendes RH, Ferreira AA, Kac G. High cholesterol dietary intake during pregnancy is associated with large for gestational age in a sample of low-income women of Rio de Janeiro, Brazil. Matern Child Nutr. 2016;13:580-7.
|
≥3 |
>90th percentile |
OR = 1.30 (0.77-2.19) |
|
|
S |
Mastroeni et al.1313 Mastroeni MF, Czarnobay SA, Kroll C, Figueirêdo KB, Mastroeni SS, Silva JC, et al. The independent importance of pre-pregnancy weight and gestational weight gain for the prevention of large-for gestational age Brazilian newborns. Matern Child Health J. 2017;21:705-14.
|
≥1 |
>90th percentile |
|
|
0.137 |
SE |
Farias et al.1414 Farias DR, Poston L, Franco-Sena AB, Silva AA, Pinto T, Oliveira LC, et al. Maternal lipids and leptin concentrations are associated with large-for-gestational-age births: a prospective cohort study. Sci Rep. 2017;7:84.
|
Child's gender
|
Male |
>4000 g |
|
|
<0.001 |
SE |
Siqueira et al.3939 Siqueira AA, Areno FB, Almeida PA, Tanaka AC. The relationship among infant birth weight and sex, and type of delivery. Rev Saude Publica. 1981;15:283-90.
|
Male |
≥4000 g |
RR = 7.50 (1.00-37.60) |
Age, marital status, parity, NB gender, pre-gestational BMI, GWG |
0.050 |
SE |
Oliveira et al.2424 Oliveira LC, Pacheco AH, Rodrigues PL, Schlussel MM, Spyrides MH, Kac G. Factors accountable for macrosomia incidence in a study with mothers and progeny attended at a Basic Unity of Health in Rio de Janeiro, Brazil. Rev Bras Ginecol Obstet. 2008;30:486-93.
|
Male |
≥4000 g |
|
|
0.014 |
SE |
Paula et al.2323 Paula HA, Salvador BC, Barbosa L, Cotta RM. Peso ao nascer e variáveis maternas no âmbito da promoção da saúde. Rev APS. 2011;14:67-74.
|
Female |
>90th percentile |
|
|
0.674 |
SE |
Castro et al.4949 Castro MB, Farias DR, Lepsch J, Mendes RH, Ferreira AA, Kac G. High cholesterol dietary intake during pregnancy is associated with large for gestational age in a sample of low-income women of Rio de Janeiro, Brazil. Matern Child Nutr. 2016;13:580-7.
|
Male |
>90th percentile |
|
|
0.269 |
S |
Kroll et al.2828 Kroll C, Mastroeni SS, Veugelers PJ, Mastroeni MF. Association of ADIPOQ, LEP, and FTO gene polymorphisms with large for gestational age infants. Am J Hum Biol. 2017;29:e22893.
|
Female |
>90th percentile |
OR = 0.93 (0.60-1.44) |
|
|
S |
Mastroeni et al.1313 Mastroeni MF, Czarnobay SA, Kroll C, Figueirêdo KB, Mastroeni SS, Silva JC, et al. The independent importance of pre-pregnancy weight and gestational weight gain for the prevention of large-for gestational age Brazilian newborns. Matern Child Health J. 2017;21:705-14.
|
Maternal height (m)
|
>1.5 |
≥4000 g |
|
|
0.001 |
NE |
Lima and Sampaio6060 Lima GS, Sampaio HA. Influência de fatores obstétricos, socioeconômicos e nutricionais da gestante sobre o peso do recém-nascido: estudo realizado em uma maternidade em Teresina, Piauí. Rev Bras Saude Matern Infant. 2004;4:253-61.
|
1.6-1.8 |
≥4000 g |
RR = 1.80 (0.60-4.80) |
|
0.280 |
SE |
Oliveira et al.2424 Oliveira LC, Pacheco AH, Rodrigues PL, Schlussel MM, Spyrides MH, Kac G. Factors accountable for macrosomia incidence in a study with mothers and progeny attended at a Basic Unity of Health in Rio de Janeiro, Brazil. Rev Bras Ginecol Obstet. 2008;30:486-93.
|
Previous macrosomia
|
|
>90th percentile |
OR = 2.37 (1.60-3.50) |
|
<0.001 |
SE |
Kerche et al.4242 Kerche LT, Abbade JF, Costa RA, Rudge MV. Calderon IdM. Fatores de risco para macrossomia fetal em gestações complicadas por diabete ou por hiperglicemia diária. Rev Bras Ginecol Obstet. 2005;27:580-7.
|
|
>90th percentile |
RR = 2.00 (1.20-3.40) |
|
|
SE |
Rehder et al.5353 Rehder PM, Pereira BG, Silva JL. Resultados gestacionais e neonatais em mulheres com rastreamento positivo para diabetes mellitus e teste oral de tolerância à glicose - 100 g normal. Rev Bras Ginecol Obstet. 2011;33:81-6.
|
|
>4000 g |
RR = 3.20 (1.50-6.60) |
|
|
SE |
Rehder et al.5353 Rehder PM, Pereira BG, Silva JL. Resultados gestacionais e neonatais em mulheres com rastreamento positivo para diabetes mellitus e teste oral de tolerância à glicose - 100 g normal. Rev Bras Ginecol Obstet. 2011;33:81-6.
|
Arterial hypertension
|
|
>90th percentile |
|
|
0.126 |
SE |
Kerche et al.4242 Kerche LT, Abbade JF, Costa RA, Rudge MV. Calderon IdM. Fatores de risco para macrossomia fetal em gestações complicadas por diabete ou por hiperglicemia diária. Rev Bras Ginecol Obstet. 2005;27:580-7.
|
|
>90th percentile |
RR = 0.80 (0.50-1.30) |
|
|
SE |
Rehder et al.5353 Rehder PM, Pereira BG, Silva JL. Resultados gestacionais e neonatais em mulheres com rastreamento positivo para diabetes mellitus e teste oral de tolerância à glicose - 100 g normal. Rev Bras Ginecol Obstet. 2011;33:81-6.
|
|
>90th percentile |
|
|
0.100 |
SE |
Nomura et al.4141 Nomura RM, Paiva LV, Costa VN, Liao AW, Zugaib M. Influência do estado nutricional materno, ganho de peso e consumo energético sobre o crescimento fetal, em gestações de alto risco. Rev Bras Ginecol Obstet. 2012;34:107-12.
|
|
>90th percentile |
|
|
0.800 |
S |
Leal et al.5757 Leal RC, Santos CN, Lima MJ, Moura SK, Pedrosa AO, Costa AC. Maternal-perinatal complications in high risk pregnancy. J Nurs UFPE on line. 2017;11:1641-9.
|
|
≥4000 g |
PR = 2.90 (1.10-7.90) |
|
|
NE |
Amorim et al.4343 Amorim MM, Leite DF, Gadelha TG, Muniz AG, Mela AS, Rocha AM. Risk factors for macrosomia in newborns at a school-maternity in northeast of Brazil. Rev Bras Ginecol Obstet. 2009;31:241-8.
|
|
>4000 g |
RR = 1.60 (0.60-3.00) |
|
|
SE |
Rehder et al.5353 Rehder PM, Pereira BG, Silva JL. Resultados gestacionais e neonatais em mulheres com rastreamento positivo para diabetes mellitus e teste oral de tolerância à glicose - 100 g normal. Rev Bras Ginecol Obstet. 2011;33:81-6.
|
Cesarean delivery
|
|
>90th percentile |
|
|
0.100 |
SE |
Nomura et al.4141 Nomura RM, Paiva LV, Costa VN, Liao AW, Zugaib M. Influência do estado nutricional materno, ganho de peso e consumo energético sobre o crescimento fetal, em gestações de alto risco. Rev Bras Ginecol Obstet. 2012;34:107-12.
|
|
>90th percentile |
|
|
0.023 |
S |
Kroll et al.2828 Kroll C, Mastroeni SS, Veugelers PJ, Mastroeni MF. Association of ADIPOQ, LEP, and FTO gene polymorphisms with large for gestational age infants. Am J Hum Biol. 2017;29:e22893.
|
|
≥4000 g |
|
|
<0.001 |
SE |
Paula et al.2323 Paula HA, Salvador BC, Barbosa L, Cotta RM. Peso ao nascer e variáveis maternas no âmbito da promoção da saúde. Rev APS. 2011;14:67-74.
|
Marital status
|
Common-law marriage |
≥4000 g |
|
|
0.980 |
NE |
Lima and Sampaio6060 Lima GS, Sampaio HA. Influência de fatores obstétricos, socioeconômicos e nutricionais da gestante sobre o peso do recém-nascido: estudo realizado em uma maternidade em Teresina, Piauí. Rev Bras Saude Matern Infant. 2004;4:253-61.
|
Married |
≥4000 g |
RR = 3.00 |
|
0.030 |
SE |
Oliveira et al.2424 Oliveira LC, Pacheco AH, Rodrigues PL, Schlussel MM, Spyrides MH, Kac G. Factors accountable for macrosomia incidence in a study with mothers and progeny attended at a Basic Unity of Health in Rio de Janeiro, Brazil. Rev Bras Ginecol Obstet. 2008;30:486-93.
|
Single/other |
≥4000 g |
|
|
0.004 |
SE |
Paula et al.2323 Paula HA, Salvador BC, Barbosa L, Cotta RM. Peso ao nascer e variáveis maternas no âmbito da promoção da saúde. Rev APS. 2011;14:67-74.
|
Single/other |
>90th percentile |
PR = 0.87 (0.40-1.87) |
|
0.717 |
SE |
Castro et al.4949 Castro MB, Farias DR, Lepsch J, Mendes RH, Ferreira AA, Kac G. High cholesterol dietary intake during pregnancy is associated with large for gestational age in a sample of low-income women of Rio de Janeiro, Brazil. Matern Child Nutr. 2016;13:580-7.
|
Married |
>90th percentile |
|
|
0.173 |
S |
Kroll et al.2828 Kroll C, Mastroeni SS, Veugelers PJ, Mastroeni MF. Association of ADIPOQ, LEP, and FTO gene polymorphisms with large for gestational age infants. Am J Hum Biol. 2017;29:e22893.
|
Single/other |
>90th percentile |
OR = 0.61 (0.32-1.16) |
|
|
S |
Mastroeni et al.1313 Mastroeni MF, Czarnobay SA, Kroll C, Figueirêdo KB, Mastroeni SS, Silva JC, et al. The independent importance of pre-pregnancy weight and gestational weight gain for the prevention of large-for gestational age Brazilian newborns. Matern Child Health J. 2017;21:705-14.
|
Per capita income <1 MW |
≥4000 g |
|
|
0.350 |
NE |
Lima and Sampaio6060 Lima GS, Sampaio HA. Influência de fatores obstétricos, socioeconômicos e nutricionais da gestante sobre o peso do recém-nascido: estudo realizado em uma maternidade em Teresina, Piauí. Rev Bras Saude Matern Infant. 2004;4:253-61.
|
Total family income (MW)
|
≥1 |
≥4000 g |
RR = 1.50 (0.50-4.20) |
|
0.450 |
SE |
Oliveira et al.2424 Oliveira LC, Pacheco AH, Rodrigues PL, Schlussel MM, Spyrides MH, Kac G. Factors accountable for macrosomia incidence in a study with mothers and progeny attended at a Basic Unity of Health in Rio de Janeiro, Brazil. Rev Bras Ginecol Obstet. 2008;30:486-93.
|
≥3 |
≥4000 g |
|
|
0.447 |
S |
Kroll et al.2828 Kroll C, Mastroeni SS, Veugelers PJ, Mastroeni MF. Association of ADIPOQ, LEP, and FTO gene polymorphisms with large for gestational age infants. Am J Hum Biol. 2017;29:e22893.
|
<3 |
≥4000 g |
OR = 0.73 (0.44-1.23) |
Schooling, smoking during pregnancy, age of first child, glycated hemoglobin |
|
S |
Mastroeni et al.1313 Mastroeni MF, Czarnobay SA, Kroll C, Figueirêdo KB, Mastroeni SS, Silva JC, et al. The independent importance of pre-pregnancy weight and gestational weight gain for the prevention of large-for gestational age Brazilian newborns. Matern Child Health J. 2017;21:705-14.
|
Total family income
|
>90th percentile |
PR = 1.01 (1.00-1.01) |
Schooling, maternal age, pre-gestational BMI, GWG, total cholesterol |
0.014 |
SE |
Castro et al.4949 Castro MB, Farias DR, Lepsch J, Mendes RH, Ferreira AA, Kac G. High cholesterol dietary intake during pregnancy is associated with large for gestational age in a sample of low-income women of Rio de Janeiro, Brazil. Matern Child Nutr. 2016;13:580-7.
|
Prenatal consultations
|
≥6 |
≥4000 g |
|
|
0.970 |
NE |
Lima and Sampaio6060 Lima GS, Sampaio HA. Influência de fatores obstétricos, socioeconômicos e nutricionais da gestante sobre o peso do recém-nascido: estudo realizado em uma maternidade em Teresina, Piauí. Rev Bras Saude Matern Infant. 2004;4:253-61.
|
≥7 |
≥4000 g |
|
|
0.001 |
SE |
Paula et al.2323 Paula HA, Salvador BC, Barbosa L, Cotta RM. Peso ao nascer e variáveis maternas no âmbito da promoção da saúde. Rev APS. 2011;14:67-74.
|
<6 |
>90th percentile |
OR = 0.69 (0.39-1.20) |
|
|
S |
Mastroeni et al.1313 Mastroeni MF, Czarnobay SA, Kroll C, Figueirêdo KB, Mastroeni SS, Silva JC, et al. The independent importance of pre-pregnancy weight and gestational weight gain for the prevention of large-for gestational age Brazilian newborns. Matern Child Health J. 2017;21:705-14.
|
Social security affiliation INPS/IPESC
|
≥4000 g |
|
|
<0.01 |
S |
Souza et al.6161 Souza ML, Tanaka ACA, Siqueira AA, Santana RM. Live births at maternity hospitals. 1. Birth weight, sex, delivery type and the mother's health insurance. Rev Saude Publica. 1988;22:489-93.
|
Age at first delivery <20 years |
>90th percentile |
OR = 1.90 (1.14-3.17) |
Schooling, family income, smoking during pregnancy, glycated hemoglobin |
|
S |
Mastroeni et al.1313 Mastroeni MF, Czarnobay SA, Kroll C, Figueirêdo KB, Mastroeni SS, Silva JC, et al. The independent importance of pre-pregnancy weight and gestational weight gain for the prevention of large-for gestational age Brazilian newborns. Matern Child Health J. 2017;21:705-14.
|
Anemia
|
>90th percentile |
RR = 3.40 (1.40-8.10) |
|
0.040 |
S |
Gonçalves et al.4545 Gonçalves CV, Mendoza-Sassi RA, Cesar JA, Castro NB, Bortolomedi AP. Body mass index and gestational weight gain as factors predicting complications and pregnancy outcome. Rev Bras Ginecol Obstet. 2012;34:304-9.
|
Level of schooling
|
<4 years |
≥4000 g |
|
|
0.570 |
NE |
Lima and Sampaio6060 Lima GS, Sampaio HA. Influência de fatores obstétricos, socioeconômicos e nutricionais da gestante sobre o peso do recém-nascido: estudo realizado em uma maternidade em Teresina, Piauí. Rev Bras Saude Matern Infant. 2004;4:253-61.
|
≤4 years |
≥4000 g |
RR = 1.80 (0.50-5.30) |
|
0.360 |
SE |
Oliveira et al.2424 Oliveira LC, Pacheco AH, Rodrigues PL, Schlussel MM, Spyrides MH, Kac G. Factors accountable for macrosomia incidence in a study with mothers and progeny attended at a Basic Unity of Health in Rio de Janeiro, Brazil. Rev Bras Ginecol Obstet. 2008;30:486-93.
|
None |
≥4000 g |
|
|
0.661 |
SE |
Paula et al.2323 Paula HA, Salvador BC, Barbosa L, Cotta RM. Peso ao nascer e variáveis maternas no âmbito da promoção da saúde. Rev APS. 2011;14:67-74.
|
9-12 years |
>90th percentile |
|
|
0.285 |
S |
Kroll et al.2828 Kroll C, Mastroeni SS, Veugelers PJ, Mastroeni MF. Association of ADIPOQ, LEP, and FTO gene polymorphisms with large for gestational age infants. Am J Hum Biol. 2017;29:e22893.
|
<8 years |
>90th percentile |
OR = 0.62 (0.32-1.20) |
Family income, smoking during pregnancy, age of first child, glycated hemoglobin |
|
S |
Mastroeni et al.1313 Mastroeni MF, Czarnobay SA, Kroll C, Figueirêdo KB, Mastroeni SS, Silva JC, et al. The independent importance of pre-pregnancy weight and gestational weight gain for the prevention of large-for gestational age Brazilian newborns. Matern Child Health J. 2017;21:705-14.
|
>8 years |
>90th percentile |
|
|
0.519 |
SE |
Farias et al.1414 Farias DR, Poston L, Franco-Sena AB, Silva AA, Pinto T, Oliveira LC, et al. Maternal lipids and leptin concentrations are associated with large-for-gestational-age births: a prospective cohort study. Sci Rep. 2017;7:84.
|
Interpregnancy interval (years)
|
≥5 |
≥4000 g |
|
|
0.660 |
NE |
Lima and Sampaio6060 Lima GS, Sampaio HA. Influência de fatores obstétricos, socioeconômicos e nutricionais da gestante sobre o peso do recém-nascido: estudo realizado em uma maternidade em Teresina, Piauí. Rev Bras Saude Matern Infant. 2004;4:253-61.
|
≥2 |
>90th percentile |
|
|
0.459 |
S |
Kroll et al.2828 Kroll C, Mastroeni SS, Veugelers PJ, Mastroeni MF. Association of ADIPOQ, LEP, and FTO gene polymorphisms with large for gestational age infants. Am J Hum Biol. 2017;29:e22893.
|
Family history of macrosomia
|
|
>90th percentile |
RR = 1.50 (0.90-2.30) |
|
|
SE |
Rehder et al.5353 Rehder PM, Pereira BG, Silva JL. Resultados gestacionais e neonatais em mulheres com rastreamento positivo para diabetes mellitus e teste oral de tolerância à glicose - 100 g normal. Rev Bras Ginecol Obstet. 2011;33:81-6.
|
|
>4000 g |
RR = 1.00 (0.50-2.20) |
|
|
SE |
Rehder et al.5353 Rehder PM, Pereira BG, Silva JL. Resultados gestacionais e neonatais em mulheres com rastreamento positivo para diabetes mellitus e teste oral de tolerância à glicose - 100 g normal. Rev Bras Ginecol Obstet. 2011;33:81-6.
|
Smoking
|
No |
>90th percentile |
|
|
0.278 |
SE |
Kerche et al.4242 Kerche LT, Abbade JF, Costa RA, Rudge MV. Calderon IdM. Fatores de risco para macrossomia fetal em gestações complicadas por diabete ou por hiperglicemia diária. Rev Bras Ginecol Obstet. 2005;27:580-7.
|
No |
>90th percentile |
|
|
0.060 |
SE |
Nomura et al.4141 Nomura RM, Paiva LV, Costa VN, Liao AW, Zugaib M. Influência do estado nutricional materno, ganho de peso e consumo energético sobre o crescimento fetal, em gestações de alto risco. Rev Bras Ginecol Obstet. 2012;34:107-12.
|
Yes |
>90th percentile |
PR = 0.53 (0.17-1.66) |
Schooling, family income, age of first child, glycated hemoglobin |
|
S |
Mastroeni et al.1313 Mastroeni MF, Czarnobay SA, Kroll C, Figueirêdo KB, Mastroeni SS, Silva JC, et al. The independent importance of pre-pregnancy weight and gestational weight gain for the prevention of large-for gestational age Brazilian newborns. Matern Child Health J. 2017;21:705-14.
|
Yes |
>90th percentile |
OR = 0.64 (0.18-2.28) |
|
|
|
|
No |
>90th percentile |
|
|
0.093 |
SE |
Farias et al.1414 Farias DR, Poston L, Franco-Sena AB, Silva AA, Pinto T, Oliveira LC, et al. Maternal lipids and leptin concentrations are associated with large-for-gestational-age births: a prospective cohort study. Sci Rep. 2017;7:84.
|
Smoking before pregnancy
|
No |
>90th percentile |
|
|
0.079 |
S |
Kroll et al.2828 Kroll C, Mastroeni SS, Veugelers PJ, Mastroeni MF. Association of ADIPOQ, LEP, and FTO gene polymorphisms with large for gestational age infants. Am J Hum Biol. 2017;29:e22893.
|
Yes |
>90th percentile |
OR = 0.58 (0.23-1.43) |
Schooling, family income, age of first child, glycated hemoglobin |
|
S |
Mastroeni et al.1313 Mastroeni MF, Czarnobay SA, Kroll C, Figueirêdo KB, Mastroeni SS, Silva JC, et al. The independent importance of pre-pregnancy weight and gestational weight gain for the prevention of large-for gestational age Brazilian newborns. Matern Child Health J. 2017;21:705-14.
|
Alcohol consumption
|
|
|
|
|
|
|
Yes |
>90th percentile |
PR = 0.62 (0.23-1.16) |
|
0.348 |
SE |
Castro et al.4949 Castro MB, Farias DR, Lepsch J, Mendes RH, Ferreira AA, Kac G. High cholesterol dietary intake during pregnancy is associated with large for gestational age in a sample of low-income women of Rio de Janeiro, Brazil. Matern Child Nutr. 2016;13:580-7.
|
No |
>90th percentile |
|
|
0.806 |
SE |
Farias et al.1414 Farias DR, Poston L, Franco-Sena AB, Silva AA, Pinto T, Oliveira LC, et al. Maternal lipids and leptin concentrations are associated with large-for-gestational-age births: a prospective cohort study. Sci Rep. 2017;7:84.
|
Use of insulin
|
>90th percentile |
|
|
0.085 |
SE |
Kerche et al.4242 Kerche LT, Abbade JF, Costa RA, Rudge MV. Calderon IdM. Fatores de risco para macrossomia fetal em gestações complicadas por diabete ou por hiperglicemia diária. Rev Bras Ginecol Obstet. 2005;27:580-7.
|
Previous miscarriage
|
≥4000 g |
RR = 1.02 (0.30-3.10) |
|
0.980 |
SE |
Oliveira et al.2424 Oliveira LC, Pacheco AH, Rodrigues PL, Schlussel MM, Spyrides MH, Kac G. Factors accountable for macrosomia incidence in a study with mothers and progeny attended at a Basic Unity of Health in Rio de Janeiro, Brazil. Rev Bras Ginecol Obstet. 2008;30:486-93.
|
Gestational age (weeks)
|
35-40 |
≥4000 g |
RR = 0.90 (0.20-3.70) |
|
0.920 |
SE |
Oliveira et al.2424 Oliveira LC, Pacheco AH, Rodrigues PL, Schlussel MM, Spyrides MH, Kac G. Factors accountable for macrosomia incidence in a study with mothers and progeny attended at a Basic Unity of Health in Rio de Janeiro, Brazil. Rev Bras Ginecol Obstet. 2008;30:486-93.
|
≥42 |
≥4000 g |
|
|
0.565 |
SE |
Paula et al.2323 Paula HA, Salvador BC, Barbosa L, Cotta RM. Peso ao nascer e variáveis maternas no âmbito da promoção da saúde. Rev APS. 2011;14:67-74.
|
White skin color
|
|
≥4000 g |
RR = 1.90 (0.60-5.00) |
|
0.230 |
SE |
Oliveira et al.2424 Oliveira LC, Pacheco AH, Rodrigues PL, Schlussel MM, Spyrides MH, Kac G. Factors accountable for macrosomia incidence in a study with mothers and progeny attended at a Basic Unity of Health in Rio de Janeiro, Brazil. Rev Bras Ginecol Obstet. 2008;30:486-93.
|
|
>90th percentile |
|
|
0.500 |
SE |
Nomura et al.4141 Nomura RM, Paiva LV, Costa VN, Liao AW, Zugaib M. Influência do estado nutricional materno, ganho de peso e consumo energético sobre o crescimento fetal, em gestações de alto risco. Rev Bras Ginecol Obstet. 2012;34:107-12.
|
|
>90th percentile |
PR = 1.38 (0.56-3.35) |
|
0.481 |
SE |
Castro et al.4949 Castro MB, Farias DR, Lepsch J, Mendes RH, Ferreira AA, Kac G. High cholesterol dietary intake during pregnancy is associated with large for gestational age in a sample of low-income women of Rio de Janeiro, Brazil. Matern Child Nutr. 2016;13:580-7.
|
Age at menarche <13 years |
≥4000 g |
RR = 1.10 (0.40-3.30) |
|
0.810 |
SE |
Oliveira et al.2424 Oliveira LC, Pacheco AH, Rodrigues PL, Schlussel MM, Spyrides MH, Kac G. Factors accountable for macrosomia incidence in a study with mothers and progeny attended at a Basic Unity of Health in Rio de Janeiro, Brazil. Rev Bras Ginecol Obstet. 2008;30:486-93.
|
Sedentary lifestyle
|
≥4000 g |
RR = 1.20 (0.20-3.10) |
|
0.740 |
SE |
Oliveira et al.2424 Oliveira LC, Pacheco AH, Rodrigues PL, Schlussel MM, Spyrides MH, Kac G. Factors accountable for macrosomia incidence in a study with mothers and progeny attended at a Basic Unity of Health in Rio de Janeiro, Brazil. Rev Bras Ginecol Obstet. 2008;30:486-93.
|
Pre-gestational physical activity
|
>90th percentile |
|
|
0.102 |
SE |
Farias et al.1414 Farias DR, Poston L, Franco-Sena AB, Silva AA, Pinto T, Oliveira LC, et al. Maternal lipids and leptin concentrations are associated with large-for-gestational-age births: a prospective cohort study. Sci Rep. 2017;7:84.
|
Preeclampsia
|
≥4000 g |
PR = 1.70 (0.60-4.70) |
|
|
NE |
Amorim et al.4343 Amorim MM, Leite DF, Gadelha TG, Muniz AG, Mela AS, Rocha AM. Risk factors for macrosomia in newborns at a school-maternity in northeast of Brazil. Rev Bras Ginecol Obstet. 2009;31:241-8.
|
Number of pregnancies ≥3 |
|
>90th percentile |
|
|
0.642 |
S |
Kroll et al.2828 Kroll C, Mastroeni SS, Veugelers PJ, Mastroeni MF. Association of ADIPOQ, LEP, and FTO gene polymorphisms with large for gestational age infants. Am J Hum Biol. 2017;29:e22893.
|
|
>90th percentile |
OR = 1.45 (0.86-2.43) |
|
|
S |
Mastroeni et al.1313 Mastroeni MF, Czarnobay SA, Kroll C, Figueirêdo KB, Mastroeni SS, Silva JC, et al. The independent importance of pre-pregnancy weight and gestational weight gain for the prevention of large-for gestational age Brazilian newborns. Matern Child Health J. 2017;21:705-14.
|
Maternal heart disease |
>90th percentile |
|
|
0.600 |
SE |
Nomura et al.4141 Nomura RM, Paiva LV, Costa VN, Liao AW, Zugaib M. Influência do estado nutricional materno, ganho de peso e consumo energético sobre o crescimento fetal, em gestações de alto risco. Rev Bras Ginecol Obstet. 2012;34:107-12.
|
Premature rupture of membranes
|
>90th percentile |
|
|
0.100 |
SE |
Nomura et al.4141 Nomura RM, Paiva LV, Costa VN, Liao AW, Zugaib M. Influência do estado nutricional materno, ganho de peso e consumo energético sobre o crescimento fetal, em gestações de alto risco. Rev Bras Ginecol Obstet. 2012;34:107-12.
|
Collagenosis
|
>90th percentile |
|
|
0.700 |
SE |
Nomura et al.4141 Nomura RM, Paiva LV, Costa VN, Liao AW, Zugaib M. Influência do estado nutricional materno, ganho de peso e consumo energético sobre o crescimento fetal, em gestações de alto risco. Rev Bras Ginecol Obstet. 2012;34:107-12.
|
Maternal energy consumption (Kcal)
|
>90th percentile |
PR = 1.00 (1.00-1.00) |
|
0.842 |
SE |
Castro et al.4949 Castro MB, Farias DR, Lepsch J, Mendes RH, Ferreira AA, Kac G. High cholesterol dietary intake during pregnancy is associated with large for gestational age in a sample of low-income women of Rio de Janeiro, Brazil. Matern Child Nutr. 2016;13:580-7.
|
Fat consumption (mg/1000
kcal)
|
Saturated: 4th quartile (11.4-18.3) |
>90th percentile |
PR = 1.34 (0.71-2.51) |
|
0.362 |
SE |
Castro et al.4949 Castro MB, Farias DR, Lepsch J, Mendes RH, Ferreira AA, Kac G. High cholesterol dietary intake during pregnancy is associated with large for gestational age in a sample of low-income women of Rio de Janeiro, Brazil. Matern Child Nutr. 2016;13:580-7.
|
Monosaturated: 4th quartile (7.7-20.0) |
>90th percentile |
PR = 1.34 (0.71-2.51) |
|
0.362 |
SE |
Castro et al.4949 Castro MB, Farias DR, Lepsch J, Mendes RH, Ferreira AA, Kac G. High cholesterol dietary intake during pregnancy is associated with large for gestational age in a sample of low-income women of Rio de Janeiro, Brazil. Matern Child Nutr. 2016;13:580-7.
|
Polyunsaturated: 4th quartile (4.2-6.8) |
>90th percentile |
PR = 1.48 (0.80-2.73) |
|
0.210 |
SE |
Castro et al.4949 Castro MB, Farias DR, Lepsch J, Mendes RH, Ferreira AA, Kac G. High cholesterol dietary intake during pregnancy is associated with large for gestational age in a sample of low-income women of Rio de Janeiro, Brazil. Matern Child Nutr. 2016;13:580-7.
|
Polymorphisms (allele)
|
Mutant G54D (maternal) |
>90th percentile |
|
|
0.149 |
S |
Baggenstoss et al.2727 Baggenstoss R, Petzhold SV, Willemann IKM, Pabis FS, Gimenes P, De Souza BV, et al. Study of polymorphism G54D of MBL2 gene in gestational diabetes mellitus. Arq Bras Endocrinol Metabol. 2014;58:900-5.
|
ADIPOQ rs2241766 mutant (NB) |
>90th percentile |
OR = 2.01 (0.90-4.47) |
Maternal age, schooling, family income, marital status, GWG, smoking before pregnancy, DM, NB gender, ADIPOQ rs2241766, LEP rs7799039, FTO rs9939609 |
0.087 |
S |
Kroll et al.2828 Kroll C, Mastroeni SS, Veugelers PJ, Mastroeni MF. Association of ADIPOQ, LEP, and FTO gene polymorphisms with large for gestational age infants. Am J Hum Biol. 2017;29:e22893.
|
Wild LEP rs7799039 (NB) |
>90th percentile |
OR = 1.98 (1.05-3.74) |
Maternal age, schooling, family income, marital status, GWG, smoking before pregnancy, DM, NB gender, ADIPOQ rs2241766, LEP rs7799039, FTO rs9939609 |
0.036 |
S |
Kroll et al.2828 Kroll C, Mastroeni SS, Veugelers PJ, Mastroeni MF. Association of ADIPOQ, LEP, and FTO gene polymorphisms with large for gestational age infants. Am J Hum Biol. 2017;29:e22893.
|
Mutant FTO rs9939609 (NB) |
>90th percentile |
OR = 1.11 (0.59-2.11) |
Maternal age, schooling, family income, marital status, GWG, smoking before pregnancy, DM, NB gender, ADIPOQ rs2241766, LEP rs7799039, FTO rs9939609 |
0.744 |
S |
Kroll et al.2828 Kroll C, Mastroeni SS, Veugelers PJ, Mastroeni MF. Association of ADIPOQ, LEP, and FTO gene polymorphisms with large for gestational age infants. Am J Hum Biol. 2017;29:e22893.
|
Total cholesterol levels: mg/1000 kcal. 4th quartile (183.5-466.7) |
>90th percentile |
PR = 2.48 (1.31-4.66) |
Maternal age, family income, pre-gestational BMI, GWG, total cholesterol |
0.005 |
SE |
Castro et al.4949 Castro MB, Farias DR, Lepsch J, Mendes RH, Ferreira AA, Kac G. High cholesterol dietary intake during pregnancy is associated with large for gestational age in a sample of low-income women of Rio de Janeiro, Brazil. Matern Child Nutr. 2016;13:580-7.
|
Levels of HDL-c cholesterol according to gestational age
|
>90th percentile |
OR = 0.02 (0.00-0.88) |
Log of triglycerides, leptin and adiponectin, maternal age, schooling, parity, pre-gestational physical activity, blood glucose, GWG, and BMI at the beginning of the pregnancy |
0.043 |
SE |
Farias et al.1414 Farias DR, Poston L, Franco-Sena AB, Silva AA, Pinto T, Oliveira LC, et al. Maternal lipids and leptin concentrations are associated with large-for-gestational-age births: a prospective cohort study. Sci Rep. 2017;7:84.
|
Levels of LDL-c cholesterol according to gestational age
|
>90th percentile |
OR = 1.52 (0.80-2.88) |
Log of triglycerides, leptin and adiponectin, maternal age, schooling, parity, pre-gestational physical activity, blood glucose, GWG, and BMI at the beginning of the pregnancy |
0.203 |
SE |
Farias et al.1414 Farias DR, Poston L, Franco-Sena AB, Silva AA, Pinto T, Oliveira LC, et al. Maternal lipids and leptin concentrations are associated with large-for-gestational-age births: a prospective cohort study. Sci Rep. 2017;7:84.
|
Levels of triglycerides according to gestational age
|
>90th percentile |
OR = 1.0e + 43 (0.00-9.5e + 88) |
Log of triglycerides, leptin and adiponectin, maternal age, schooling, parity, pre-gestational physical activity, blood glucose, GWG, and BMI at the beginning of pregnancy |
0.067 |
SE |
Farias et al.1414 Farias DR, Poston L, Franco-Sena AB, Silva AA, Pinto T, Oliveira LC, et al. Maternal lipids and leptin concentrations are associated with large-for-gestational-age births: a prospective cohort study. Sci Rep. 2017;7:84.
|
Log of leptin concentration in the first trimester of pregnancy
|
>90th percentile |
OR = 3.92 (1.18-12.95) |
Log of triglycerides, leptin and adiponectin, maternal age, schooling, parity, pre-gestational physical activity, blood glucose, GWG, and BMI at the beginning of the pregnancy |
0.025 |
SE |
Farias et al.1414 Farias DR, Poston L, Franco-Sena AB, Silva AA, Pinto T, Oliveira LC, et al. Maternal lipids and leptin concentrations are associated with large-for-gestational-age births: a prospective cohort study. Sci Rep. 2017;7:84.
|
Log of adiponectin levels in the first trimester of pregnancy
|
>90th percentile |
OR = 0.54 (0.16-1.83) |
Log of triglycerides, leptin and adiponectin, maternal age, schooling, parity, pre-gestational physical activity, blood glucose, GWG, and BMI at the beginning of the pregnancy |
0.321 |
SE |
Farias et al.1414 Farias DR, Poston L, Franco-Sena AB, Silva AA, Pinto T, Oliveira LC, et al. Maternal lipids and leptin concentrations are associated with large-for-gestational-age births: a prospective cohort study. Sci Rep. 2017;7:84.
|
Presence of urinary tract infection
|
>90th percentile |
|
|
0.220 |
S |
Leal et al.5757 Leal RC, Santos CN, Lima MJ, Moura SK, Pedrosa AO, Costa AC. Maternal-perinatal complications in high risk pregnancy. J Nurs UFPE on line. 2017;11:1641-9.
|
Presence of sexually transmitted disease
|
>90th percentile |
|
|
0.370 |
S |
Leal et al.5757 Leal RC, Santos CN, Lima MJ, Moura SK, Pedrosa AO, Costa AC. Maternal-perinatal complications in high risk pregnancy. J Nurs UFPE on line. 2017;11:1641-9.
|