Abstract

GANEM, Eliana M; FABRIS, Paula; MORO, Marlene Z  and  CASTIGLIA, Yara Marcondes Machado. Efficacy of ondansetron and alizapride in preventing gynecological laparoscopy nausea and vomiting. Rev. Bras. Anestesiol. [online]. 2001, vol.51, n.5, pp. 401-406. ISSN 0034-7094.  http://dx.doi.org/10.1590/S0034-70942001000500005.

BACKGROUND AND OBJECTIVES: Gynecological laparoscopy is a procedure with a high incidence of postoperative nausea and vomiting (PONV). This study aimed at comparing the efficacy of ondansetron and alizapride in preventing PONV in patients submitted to gynecological laparoscopy. METHODS: Participated in this study 52 women physical status ASA I and II, aged 21 to 50 years, without previous gastric complaint, who were submitted to diagnostic or surgical laparoscopy. Patients were distributed in 2 groups: Group 1 - intravenous ondansetron (4 mg) and Group 2 - intravenous alizapride (50 mg), before anesthetic induction. All patients were premedicated with oral midazolam (7.5 mg), were induced with sufentanil (0,5 µg.kg^-1) and propofol (2 mg.kg^-1). Propofol (115 µg.kg^-1) and N₂O/O₂ (F_IO₂ = 40%) were used for maintenance, and atracurium (0,5 mg.kg^-1) was the neuromuscular blocker. Postoperative analgesia was achieved with cetoprofen (100 mg) and buscopam composto^®. RESULTS: Both groups were identical in demographics and surgery and anesthesia duration. One Group 1 patient referred nausea. One Group 2 patients referred nausea and 3 referred vomiting, but results were not statistically significant. CONCLUSIONS: Ondansetron and alizapride were comparable in preventing PONV in patients submitted to gynecological laparoscopy.

Keywords : ANTIEMETICS [alizapride]; ANTIEMETICS [ondansetron]; COMPLICATIONS [nausea]; COMPLICATIONS [vomiting]; SURGERY, Gynecological [laparoscopy].