Revista Brasileira de Anestesiologia
Print version ISSN 0034-7094
CESAR, Daniel Sousa; MIYOSHI, Erika; HALPERN, Hélio and AULER JUNIOR, José Otávio Costa. Fenoldopan: a new parenteral anti-hypertensive; an alternative to nitroprusside. Rev. Bras. Anestesiol. [online]. 2001, vol.51, n.6, pp. 528-536. ISSN 0034-7094. http://dx.doi.org/10.1590/S0034-70942001000600008.
Background and Objectives: Fenoldopan is a selective dopaminergic agonist for dopaminergic receptors type 1 (DA-1), which induces peripheral vasodilation. This review aimed at collecting clinical information about this drug. Contents: This study reviewed experiences in hypertensive urgencies and emergencies and has shown the advantages of fenoldopan as compared to sodium nitroprusside. As opposed to sodium nitroprusside, fenoldopan induces peripheral vasodilation at the same time that induces diuresis and natriuresis in severely hypertensive patients without the harmful effects of thiocyanate. Conclusions: Parenteral fenoldopan, for its renal effects and less adverse effects, is an interesting alternative to sodium nitroprusside in treating hypertensive emergencies.
Keywords : ANTI-HYPERTENSIVE [fenoldopan].