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Revista Brasileira de Anestesiologia
Print version ISSN 0034-7094
BRAZ, Leandro Gobbo et al. Sedation levels of oral preanesthetic clonidine and midazolam: clinical and electroencephalographic bispectral analysis. Rev. Bras. Anestesiol. [online]. 2002, vol.52, n.1, pp.9-18. ISSN 0034-7094. http://dx.doi.org/10.1590/S0034-70942002000100002.
BACKGROUND AND OBJECTIVES: This study aimed at evaluating clonidine - an a2-agonist - and midazolam - a benzodiazepine - sedative effects in preanesthetic medication by clinical and electroencephalographic analysis. METHODS: After institutional approval and their informed written consent, participated in this study 45 patients aged 18 to 65 years, physical status ASA I, who were randomly distributed in placebo (P), clonidine (C) or midazolam (M) groups. Patients were premedicated with oral placebo, 150 µg clonidine or 15 mg midazolam 60 minutes before anesthetic induction (n = 15 per group). Monitoring consisted of electrocardiogram (DII), non-invasive blood pressure, heart rate, oxygen saturation, respiratory rate, axillary and operating room temperature and bispectral electroencephalography to determine bispectral index (BIS). These attributes and sedation scale (1-anxious, 2-calm, 3-sleepy, 4-sleeping with reflex, 5-sleeping without reflex) were obtained at 0 (M0), 15 (M15), 30 (M30), 40 (M40), 50 (M50) and 60 (M60) minutes after medication. RESULTS: There were no significant differences in respiratory, hemodynamic and temperature parameters. There has been a significant difference among groups in sedation scale (M60: M=C>P) and BIS (M50 and M60: M=C>P). CONCLUSIONS: In our conditions, clonidine and midazolam have determined similar sedation levels in patients ASA I when evaluated by sedation scale and BIS. No hemodynamic and respiratory changes were observed with both drugs.
Keywords : MONITORING [depth of anesthesia]; MONITORING [bispectral index]; PREANESTHETIC MEDICATION [clonidine]; PREANESTHETIC MEDICATION [midazolam]; SEDATION [level].