SciELO - Scientific Electronic Library Online

vol.52 issue2Postoperative analgesia in pediatric patients: comparative study among local anesthetics, opioids and non-steroidal anti-inflammatory drugsTemperature and acid-base balance in coronary bypass grafting with cardiopulmonary bypass, under hypothermia and normothermia author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Revista Brasileira de Anestesiologia

Print version ISSN 0034-7094On-line version ISSN 1806-907X


MODOLO, Norma Sueli Pinheiro et al. Onset time and duration of rocuronium, atracurium and mivacurium in pediatric patients. Rev. Bras. Anestesiol. [online]. 2002, vol.52, n.2, pp.185-196. ISSN 0034-7094.

BACKGROUND AND OBJECTIVES: Neuromuscular blockers (NMB) are widely used in pediatric anesthesia, but there is no ideal NMB. This study aimed at evaluating onset and recovery time, hemodynamic changes and tracheal intubation conditions of rocuronium, atracurium and mivacurium in pediatric patients. METHODS: Participated in this study 67 children aged 30 months to 12 years, physical status ASA I and II, who were allocated into three groups: G1 = 0.9 rocuronium (n = 22); G2 = 0.5 atracurium (n = 22); G3 = 0.15 mivacurium (n = 23). Anesthesia was induced with 50 µ alfentanil, 3 propofol, sevoflurane and N2O/O2. Neuromuscular block was monitored by acceleromyography on the ulnar nerve pathway. The following parameters were evaluated: onset time (OT), clinical duration (T25) relaxation time (T75) and recovery time (T25-75). Heart rate (HR) and mean blood pressure (MBP) were recorded in 6 moments, as well as tracheal intubation conditions. RESULTS:  Median OT was: G1 = 0.6 min, G2 = 1.3 min, G3 = 1.9 min. Median T25 was: G1 = 38 min, G2 = 41.5, G3 = 8.8 min. Median T75 was: G1 = 57.7 min; G2 = 54.6 min, G3 = 13.6 min. Median T25-75 was: G1 = 19.7 min, G2 = 13.1 min and G3 = 4.8 min. Tracheal intubation conditions were excellent for most children in all groups. There were no significant MBP and HR clinical changes. CONCLUSIONS: Rocuronium (0.9 had the fastest onset time and mivacurium (0.15 the shortest recovery time in pediatric patients anesthetized with sevoflurane. Rocuronium, mivacurium and atracurium had also not determined significant hemodynamic changes and allowed for excellent tracheal intubation conditions.

Keywords : ANESTHESIA, Pediatric; MONITORING [acceleromyography]; NEUROMUSCULAR BLOCKERS, Nondepolarizing [atracurium]; NEUROMUSCULAR BLOCKERS, Nondepolarizing [mivacurium]; NEUROMUSCULAR BLOCKERS, Nondepolarizing [rocuronium].

        · abstract in Portuguese | Spanish     · text in English | Portuguese     · English ( pdf epdf ) | Portuguese ( pdf epdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License