Revista Brasileira de Anestesiologia
Print version ISSN 0034-7094
MUNHOZ, Derli Conceição; BRAGA, Angélica de Fátima de Assunção and POTERIO, Glória Maria Braga. Influence of propofol and etomidate on rocuronium-induced euromuscular block: evaluation with acceleromyography. Rev. Bras. Anestesiol. [online]. 2002, vol.52, n.6, pp. 673-680. ISSN 0034-7094. http://dx.doi.org/10.1590/S0034-70942002000600003.
BACKGROUND AND OBJECTIVES: Some hypnotics may interact with neuromuscular blockers and potentiate their effects. This study aimed at evaluating the influence of propofol and etomidate on rocuronium-induced neuromuscular block. METHODS: Participated in this study 60 patients, physical status ASA I and II, scheduled for elective surgeries under general anesthesia, who were randomly distributed in two groups according to the hypnotic drug: Group I (propofol) and Group II (etomidate). All patients were premedicated with intramuscular midazolam (0.1 mg.kg-1), 30 minutes before surgery. Anesthesia was induced with propofol (2.5 mg.kg-1) or etomidate (0.3 mg.kg-1) preceded by alfentanil (50 µg.kg-1) and followed by rocuronium (0.6 mg.kg-1). Patients were ventilated under mask with 100% oxygen until achieving a decrease of 75% or more in the adductor pollicis muscle response amplitude. Neuromuscular function was monitored by accelerometry. The following parameters were evaluated: rocuronium onset (T1 £ 25%); time for complete neuromuscular block; neuromuscular block degree at tracheal intubation; tracheal intubation conditions and hemodynamic effects. RESULTS: Complete rocuronium-induced neuromuscular block onset times (in seconds) were: Group I (48.20 ± 10.85 s and 58.87 ± 10.73 s) and Group II (51.20 ± 13.80 s and 64.27 ± 18.55 s). Neuromuscular block degree at tracheal intubation was: Group I (77.50%) and Group II (76.96%). Tracheal intubation conditions were satisfactory in 100% of Group I patients and in 83.33% of Group II patients. There has been a significant decrease in mean blood pressure, followed by an increase after hypnotic injection, in both groups. CONCLUSIONS: Propofol and etomidate had a similar behavior regarding time for rocuronium-induced neuromuscular block and tracheal intubation conditions.
Keywords : HYPNOTICS [propofol]; HYPNOTICS [etomidate]; MEASUREMENT TECHNIQUES [acceleromyography]; NEUROMUSCULAR BLOCKERS [Nondepolarizing]; NEUROMUSCULAR BLOCKERS [rocuronium].