SciELO - Scientific Electronic Library Online

vol.53 issue1Latex allergyPreoperative assessment of lung disease patients author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Revista Brasileira de Anestesiologia

Print version ISSN 0034-7094On-line version ISSN 1806-907X


VILLELA, Nivaldo Ribeiro  and  NASCIMENTO JUNIOR, Paulo do. Dexmedetomidine in anesthesiology. Rev. Bras. Anestesiol. [online]. 2003, vol.53, n.1, pp.97-113. ISSN 0034-7094.

BACKGROUND AND OBJECTIVES: Dexmedetomidine is a new a2-adrenergic agonist with a selectivity ratio of 1600:1 (a2:a1). It has important sedative and analgesic effects, good hemodynamic control at stress situations and may, by itself, induce anesthesia. This drug has been used to promote postoperative and intensive care sedation and analgesia. Due to such properties, dexmedetomidine has recently become a co adjuvant drug for anesthesia. So, this is a review of the literature about dexmedetomidine in anesthesia. CONTENTS: Major studies on dexmedetomidine in Anesthesiology are presented, both as premedication and during anesthesia. Action mechanisms of a2-adrenergic agonists and dexmedetomidine pharmacokinetic and pharmacodynamic properties are also reviewed in this paper. CONCLUSIONS: Dexmedetomidine premedication, infusion during anesthesia or in the postoperative period improves hemodynamic stability. Anesthetic consumption is decreased during anesthesia. Patients sedated with dexmedetomidine may awake, when requested and become cooperative. Even high dexmedetomidine doses do not cause respiratory depression. Bradycardia is a frequent side effect which may be minimized by slow drug infusion. So, dexmedetomidine is an important additional resource to anesthetic practice that may be used in different patients and surgical procedures.

Keywords : ANALGESICS [dexmedetomidine].

        · abstract in Portuguese | Spanish     · text in Portuguese     · Portuguese ( pdf epdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License