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Revista Brasileira de Anestesiologia
On-line version ISSN 1806-907X
GANEM, Eliana Marisa et al. Effects of low spinal morphine doses associated to intravenous and oral ketoprofen in patients submitted to cesarean sections. Rev. Bras. Anestesiol. [online]. 2003, vol.53, n.4, pp. 431-439. ISSN 1806-907X. http://dx.doi.org/10.1590/S0034-70942003000400002.
BACKGROUND AND OBJECTIVES: Low spinal morphine doses are effective in relieving postoperative pain of patients submitted to Cesarean sections, with low incidence of side-effects. This study aimed at evaluating postoperative analgesia and the incidence of side-effects in patients submitted to Cesarean sections under spinal anesthesia with hyperbaric bupivacaine and 0.05 mg and 0.1 mg morphine associated to intravenous and oral ketoprofen. METHODS: Sixty pregnant women, physical status ASA I and II, undergoing elective Cesarean sections, were divided in two groups: group 1 patients were given 0.1 mg spinal morphine, while group 2 received 0.05 mg morphine, both associated to 15 mg hyperbaric bupivacaine. All patients received perioperative 100 mg intravenous ketoprofen and oral ketoprofen at 8-hour intervals in the first postoperative day. Patients were assessed at 6, 12 and 24 hours after surgery for pain intensity and side-effects (sedation, pruritus, nausea and vomiting). Side-effects were also evaluated in the perioperative period. RESULTS: Both groups were similar in demographics and surgery and anesthesia duration. They were also homogeneous in postoperative pain intensity and presence of pruritus, sedation, nausea and vomiting. CONCLUSIONS: Spinal 0.05 mg and 0.1 mg morphine associated to intravenous and oral ketoprofen have provided the same postoperative analgesia and have determined the same incidence of side-effects.
Keywords : ANALGESICS [Opioids]; ANALGESICS [morphine]; ANALGESICS [Anti-inflamatory]; ANALGESICS [ketoprofen]; ANESTHETIC TECHNIQUES [Regional]; ANESTHETIC TECHNIQUES [spinal block]; SURGERY [Obstetric]; SURGERY [cesarian section].