SciELO - Scientific Electronic Library Online

 
vol.53 issue4Postanesthetic routines of Brazilian anesthesiologistsHemoglobin-based blood substitutes: current status and perspectives author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Revista Brasileira de Anestesiologia

On-line version ISSN 1806-907X

Abstract

MENDES, Florentino Fernandes  and  GOMES, Marcos Emanuel Wortmann. Xenon: pharmacology and clinical use. Rev. Bras. Anestesiol. [online]. 2003, vol.53, n.4, pp. 535-542. ISSN 1806-907X.  http://dx.doi.org/10.1590/S0034-70942003000400013.

BACKGROUND AND OBJECTIVES: Xenon is a colorless, odorless, inert, non-irritating, non-pollutant, non-explosive, stable gas with low solubility coefficient and anesthetic properties. This review aimed at describing some pharmacological aspects and the clinical use of xenon in anesthesia. CONTENTS: Xenon is an extremely rare gas with MAC of 0.63 to 0.71, MAC-awaken of 0.32 ± 5% and solubility coefficient of 0.14, providing fast, pleasant and well tolerated anesthetic induction, as well as 2 to 3 times faster recovery as compared to other agents. It has beneficial analgesic and minimal cardiovascular effects. Xenon may increase pulmonary resistance and produce the second gas effect, although not as important as N2O. It increases brain flow, intra-cranial pressure and cerebral perfusion pressure. Xenon is able to prevent adrenal gland stimulation. CONCLUSIONS: Xenon anesthetic properties grant it considerable advantages over other inhalational agents used in anesthesia. However, its high production costs make it prohibitive as compared to other existing techniques. New studies are being conducted with the aim of developing a more cost-effective method for using this gas.

Keywords : ANESTHETICS [Gaseous]; ANESTHETICS [xenon].

        · abstract in Portuguese | Spanish     · text in Portuguese     · Portuguese ( pdf epdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License