Revista Brasileira de Anestesiologia
On-line version ISSN 1806-907X
BISINOTTO, Flora Margarida Barra and BRAZ, José Reinaldo Cerqueira. Effects of halothane, isoflurane and sevoflurane on renal function in dogs under infra-renal aortic cross-clamping. Rev. Bras. Anestesiol. [online]. 2003, vol.53, n.6, pp. 767-783. ISSN 1806-907X. http://dx.doi.org/10.1590/S0034-70942003000600008.
BACKGROUND AND OBJECTIVES: Infra-renal aortic cross-clamping is associated to renal effects. This study aimed at analyzing halothane, isoflurane and sevoflurane effects on renal function of dogs submitted to infra-renal aortic cross-clamping. METHODS: This study involved 30 mixed-breed dogs randomly distributed in three groups, according to equipotent anesthetic doses (0.75 MAC) of inhaled anesthetics: GH (n = 10) - 0.67% halothane; GI (n = 10) - 0.96% isoflurane; and GS (n = 10) - 1.8% sevoflurane. All animals were submitted to infra-renal aortic cross-clamping for 30 minutes. Renal parameters were evaluated at control (C), 15 (Ao15) and (Ao30) minutes after aortic cross-clamping, and 15 (DAo15) and 30 (DAo30) minutes after aortic unclamping. RESULTS: Free water clearance was significantly lower in GI and GS as compared to GH (p < 0.05) after aortic unclamping. Urinary output, sodium urinary excretion and sodium clearance have significantly increased during aortic cross-clamping, while urinary osmolarity has decreased in all groups (p < 0.05). Renal vascular resistance and filtration fraction have increased during aortic cross-clamping in GS only, while sodium fractional excretion increased in GH and GI (p < 0.05). All renal parameters had returned to control levels after aortic unclamping, with the exception of urinary osmolality which has remained below control levels in all groups (p < 0.05). Renal vascular resistance and filtration fraction have remained higher in GS, followed by renal blood flow and PAH clearance decrease (p < 0.05). CONCLUSIONS: In dogs under our experimental conditions, 0.75 MAC of halothane or isoflurane, but not 0.75 MAC of sevoflurane, have minimized renal vascular resistance increase, which is the major infra-renal aortic cross-clamping effect.
Keywords : ANESTHETICS [Volatile]; ANESTHETICS [halothane]; ANESTHETICS [isoflurane]; ANESTHETICS [sevoflurane]; ANIMAL [dog]; SURGERY [Vascular]; SURGERY [infra-renal aortic cross-clamping].