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Revista Brasileira de Anestesiologia

Print version ISSN 0034-7094On-line version ISSN 1806-907X


STOCCHE, Renato Mestriner et al. Influence of intravenous clonidine in the cost of sevoflurane anesthesia for outpatient middle ear procedures. Rev. Bras. Anestesiol. [online]. 2004, vol.54, n.1, pp.91-98. ISSN 0034-7094.

BACKGROUND AND OBJECTIVES: Clonidine is an a2-agonist which decreases intravenous and inhalational anesthetics consumption. This study aimed at evaluating the cost-benefit ratio of preanesthetic medication with intravenous clonidine for general anesthesia with sevoflurane in outpatient procedures. METHODS: Forty five patients aged 15 to 52 years were included in this double-blind, randomized and placebo controlled study, and were distributed in 3 groups of 15: Group S (placebo), Group C3 (3 µ clonidine) and Group C5 (5 µ clonidine). Anesthesia was induced with sevoflurane, alfentanil (30 µ and pancuronium (0.08 The following parameters were recorded: incidence of complications, halogenate consumption and anesthesia duration, as well as phase I and II recovery time. Cost analysis has considered direct and indirect costs. RESULTS: There were no differences among groups in demographics data, incidence of complications and phase I anesthetic recovery. Phase II anesthetic recovery was prolonged in Group C5 (p < 0.05). Sevoflurane consumption per minute of surgery was 0.54 ± 0.14, 0.33 ± 0.09 and 0.34 ± 0.13 in Groups S, C3 and C5 respectively (p < 0.05). Costs were approximately 35% lower in the clonidine groups. CONCLUSIONS: Intravenous clonidine (3 µ decreases sevoflurane consumption without prolonging phase I recovery. Although decreasing sevoflurane consumption, 5 µ clonidine prolongs phase II recovery, thus being inadequate for outpatient procedures.

Keywords : ANESTHESIA [Ambulatory]; ANESTHETICS, Volatile [sevoflurane]; DRUGS, a2- agonist [clonidine].

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