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Revista Brasileira de Anestesiologia
On-line version ISSN 1806-907X
OLIVEIRA, Caio Márcio Barros de; SAKATA, Rioko Kimiko; ISSY, Adriana Machado and GARCIA, João Batista Santos. Ketamine and preemptive analgesia. Rev. Bras. Anestesiol. [online]. 2004, vol.54, n.5, pp.739-752. ISSN 1806-907X. http://dx.doi.org/10.1590/S0034-70942004000500016.
BACKAGROUND AND OBJECTIVES: Since the finding that ketamine blocks NMDA receptors in the neurons of spinal dorsal horn, it has been used to inhibit or decrease central sensitization triggered by nociceptive stimulations. This study aimed at presenting pharmacological aspects of racemic ketamine and its levogyrous compound, as well as its usefulness for preemptive analgesia. CONTENTS: Current preemptive analgesia concepts, pharmacological aspects of ketamine and its levogyrous compound, as well as experimental and clinical trials on ketamine and its use in preemptive analgesia are presented. CONCLUSIONS: The efficacy of ketamine in inhibiting or decreasing central sensitization triggered by nociceptive stimulations is not totally confirmed, probably due to different study and statistical analysis methods.
Keywords : ANALGESIA [Preemptive]; ANESTHETICS [Venous]; ANESTHETICS [ketamine].