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Revista Brasileira de Anestesiologia
Print version ISSN 0034-7094
On-line version ISSN 1806-907X
HERBERT, Bernardo Aloisio Grings et al. The use of dexmedetomidine in neurosurgery. Rev. Bras. Anestesiol. [online]. 2007, vol.57, n.2, pp.223-231. ISSN 0034-7094. http://dx.doi.org/10.1590/S0034-70942007000200012.
BACKGROUND AND OBJECTIVES: The use of a2-adrenergic agonists is increasingly more frequent in Anesthesiology, as adjuvant or the sole anesthetic drug. Currently, dexmedetomidine is gaining popularity due to its greater selectivity for the a2-adrenergic receptors and its pharmacokinetic profile. The aim of this review was to analyze the use of dexmedetomidine in neurosurgery. CONTENTS: Besides considerations and review of the literature regarding the use of dexmedetomidine, specifically in neurosurgical procedures, its effects on the different organ systems are described. CONCLUSIONS: The pharmacokinetic and pharmacodynamic profile of dexmedetomidine favors its use in several neurosurgical procedures. Its use in craniotomy for the treatment of aneurysms and tumor removal is recent. Besides, its use in functional surgical interventions is promising.
Keywords : DRUGS, Adrenergic Agonists [dexmedetomidine]; SURGERY, Neurosurgery.