SciELO - Scientific Electronic Library Online

 
vol.58 issue3Cannabinoids in chronic pain and palliative careDepression in patients with advanced cancer and pain author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Revista Brasileira de Anestesiologia

Print version ISSN 0034-7094

Abstract

LAURETTI, Gabriela Rocha. Mechanisms of analgesia of intravenous lidocaine. Rev. Bras. Anestesiol. [online]. 2008, vol.58, n.3, pp. 280-286. ISSN 0034-7094.  http://dx.doi.org/10.1590/S0034-70942008000300011.

BACKGROUND AND OBJECTIVES: Intravenous lidocaine has been used for several indications since the decade of 1960. Its multimodal mechanism of action was the objective of this review. CONTENTS: Mechanisms of action that diverge from the classical Na+ channel blockade, the differential action of intravenous lidocaine in central sensitization, and the analgesic and cytoprotective actions, as well as the different doses of intravenous lidocaine were reviewed. CONCLUSIONS: The final analgesic action of intravenous lidocaine is a reflection of its multifactorial action. It has been suggested that its central sensitization is secondary to a peripheral anti-hyperalgic action on somatic pain and central on neuropathic pain, which result on the blockade of central hyperexcitability. The intravenous dose should not exceed the toxic plasma concentration of 5 µg.mL-1; doses smaller than 5 mg.kg-1, administered slowly (30 minutes), under monitoring, are considered safe.

Keywords : ANALGESIA [lidocaine]; ANALGESIA [mechanisms of action]; ANALGESIA [intravenous].

        · abstract in Portuguese | Spanish     · text in English | Portuguese     · pdf in English | Portuguese