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Revista Brasileira de Anestesiologia
On-line version ISSN 1806-907X
TANAKA, Pedro Paulo and MOSS, Jonathan. The role of peripheral opiate antagonists in pain medicine and perioperative care. Rev. Bras. Anestesiol. [online]. 2008, vol.58, n.5, pp. 533-547. ISSN 1806-907X. http://dx.doi.org/10.1590/S0034-70942008000500011.
BACKGROUND AND OBJECTIVES: Pre-clinical and clinical trials of peripheral opiate antagonists have shed new light on the effects of exogenous and endogenous opioids. CONTENTS: This article review preclinical studies and clinical opioid bowel disfunction trials. CONCLUSIONS: If approved these drugs may offer potential solutions to important clinical problems in pain management.
Keywords : ANALGESICS, Opioids [antagonists]; COMPLICATIONS [constipation].