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Revista Brasileira de Anestesiologia
On-line version ISSN 1806-907X
IMBELLONI, Luiz Eduardo and CORDEIRO, José Antônio. 50% enantiomeric excess hyperbaric bupivacaine (S75:R25) for infraumbilical surgeries: study with different volumes. Rev. Bras. Anestesiol. [online]. 2009, vol.59, n.1, pp.3-10. ISSN 1806-907X. http://dx.doi.org/10.1590/S0034-70942009000100002.
BACKGROUND AND OBJECTIVES: Hyperbaric bupivacaine is commercially available in its racemic form. In Brazil, 50% enantiomeric excess bupivacaine (S75:R25) was introduced as an isobaric presentation. The objective of this study was to evaluate different volumes of hyperbaric S75:R25 bupivacaine in spinal blocks for infraumbilical surgeries. METHODS: Forty patients, ages 20 to 60 years, physical status ASA I and II, scheduled for infraumbilical surgeries under spinal block participated in this study. Patients were randomly divided in four groups of 10 patients: Group 2.5 received 2.5 ml of the solution (10 mg), Group 3 - 3 ml (12 mg), Group 4 - 4 ml (16 mg), and Group 5 - 5 ml (20 mg). The following parameters were evaluated and compared: latency, cephalad dispersion, motor blockade, cardiovascular changes, and neurologic complications. RESULTS: The study showed a latency of 1:33 ± 0:26 (min:sec) without significant differences among the different doses. Motor blockade was dose-dependent. The incidence of bradycardia or hypotension was related with the increase in the dose. Anesthetic failures were not observed. CONCLUSIONS: 0.4% hyperbaric 50% enantiomeric excess bupivacaine (S75:R25) with D5W provided fast onset of the blockade and the level of sensitive and motor blockades as well as the duration of the blockade were dose-dependent.
Keywords : ANESTHETIC TECHNIQUES, Regional [subarachnoid]; ANESTHETICS, Local [50% enantiomeric excess bupivacaine].