SciELO - Scientific Electronic Library Online

vol.59 issue2Regional anesthesia and non-preeclamptic thrombocytopenia: time to re-think the safe platelet countInfluence of the anesthetic technique on the hemodynamic changes in renal transplantation: a retrospective study author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Revista Brasileira de Anestesiologia

Print version ISSN 0034-7094On-line version ISSN 1806-907X


IMBELLONI, Luiz Eduardo et al. Assessment of the densities of local anesthetics and their combination with adjuvants: an experimental study. Rev. Bras. Anestesiol. [online]. 2009, vol.59, n.2, pp.154-165. ISSN 0034-7094.

BACKGROUND AND OBJECTIVES: The relative density of a local anesthetic in relation to that of the cerebrospinal fluid (CSF) at 37° C is one of the most important physical properties that affect the level of analgesia obtained after the subarachnoid administration of the drug. The objective of this study was to determine the density of local anesthetic solutions, with and without glucose, and the combination of the local anesthetic with adjuvants at 20° C, 25° C, and 37° C. METHODS: The density (g.mL-1) was determined by using a DMA 450 densimeter with a sensitivity of ± 0.00001 g.mL-1. The densities, and variations, according to the temperature were obtained for all local anesthetics and their combination with opioids at 20ºC, 25°C, and 37°C. The solution is hyperbaric if its density exceeds 1.00099, hypobaric when its density is lower than 1.00019, and isobaric when its density is greater than 1.00019 and lower than 1.00099. RESULTS: The densities of both local anesthetics and adjuvants decrease with the increase in temperature. At 37° C, all glucose-containing solutions are hyperbaric. In the absence of glucose, all solutions are hypobaric. At 37°C, morphine, fentanyl, sufentanil, and clonidine are hypobaric. CONCLUSIONS: The densities of local anesthetics and adjuvants decrease with the increase in temperature and increase when glucose is added. The knowledge of the relative density helps select the most adequate local anesthetic to be administered in the subarachnoid space.

Keywords : ANALGESICS [clonidine]; ANALGESICS [fentanyl, morphine]; ANALGESICS [sufentanil]; ANESTHETICS, Local [bupivacaine]; ANESTHETICS, Local [50% enantiomeric excess bupivacaine]; ANESTHETICS, Local [lidocaine]; PHARMACOLOGY [density].

        · abstract in Portuguese | Spanish     · text in English | Portuguese     · English ( pdf epdf ) | Portuguese ( pdf epdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License