SciELO - Scientific Electronic Library Online

vol.61 issue1Triceratium moreirae sp. nov. and Triceratium dubium (Triceratiaceae - Bacillariophyta) from estuarine environments of Southern Brazil, with comments on the genus Triceratium C. G. Ehrenberg author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Revista Brasileira de Biologia

Print version ISSN 0034-7108


GUERRA, M. de O.; MAZONI, A. S. B.; BRANDAO, M. A. F.  and  PETERS, V. M.. Toxicology of Lapachol in rats: embryolethality. Rev. Bras. Biol. [online]. 2001, vol.61, n.1, pp.171-174. ISSN 0034-7108.

Lapachol is a naphtoquinone with therapeutic potential against enterovirus, Chagas disease and is also used as an antimalarial and antiinflamatory agent. In order to study teratogenic potential of Lapachol, pregnant Wistar rats were treated with 0.5 ml of distilled water (control group); 0.5 ml of hydroalcoholic solution (vehicle group) and 10 mg of Lapachol in 0.5 ml of hydroalcoholic solution (treated group) by oral gavage from the 8th to the 12th day of pregnancy. The following variables were observed: maternal body weight on days 1, 6, l5 and 21 and food intake on days 2, 6, 15 and 21 of pregnancy. The number of live and dead fetuses and the sites of resorptions were counted. The ovaries were weighed and the corpora lutea were counted. Data were analyzed by ANOVA-one way, Dunnett test and the chi square test. Significance level test a = 0.05. Results have shown that mothers were unaffected but there were a 99.2% of fetus mortality, indicative of a strong abortifacient effect of Lapachol in rats.

Keywords : Lapachol; embryotoxicity; rat.

        · abstract in Portuguese     · text in English     · English ( pdf epdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License