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Revista Brasileira de Biologia

Print version ISSN 0034-7108

Abstract

VALSA, J. O.  and  FELZENSZWALB, I.. Genotoxic evaluation of the effect of Thuya occidentalys tinctures. Rev. Bras. Biol. [online]. 2001, vol.61, n.2, pp. 329-332. ISSN 0034-7108.  http://dx.doi.org/10.1590/S0034-71082001000200017.

Three tinctures samples from extracts of the popular medicinal plant Thuya occidentalis were tested in vitro through two short term tests for measuring the activity of genotoxic chemicals. Using the Salmonella/mammalian-microsome (Mutatest) assay and the SOS-chromotest (induction of b-galactosidase in Escherichia coli), none of the extract was effective in inducing mutagenesis or b-galactosidase synthesis (as an indicator of general and early sign of DNA damage), even with metabolization.

Keywords : Thuya occidentalis; Salmonella [mammalian-microsome assay]; SOS-chromotest; popular medicine.

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