Revista Brasileira de Oftalmologia
Print version ISSN 0034-7280
GARCIA FILHO, Carlos Alexandre de Amorim; PENHA, Fernando Marcondes and GARCIA, Carlos Alexandre de Amorim. Wet-amd treatment: a review in the anti-vegf drugs. Rev. bras.oftalmol. [online]. 2012, vol.71, n.1, pp.63-69. ISSN 0034-7280. http://dx.doi.org/10.1590/S0034-72802012000100013.
Neovascular age-related macular degeneration is the leading cause of severe, irreversible vision loss in individuals over 50 years in developed countries. Vascular endothelial growth factor (VEGF) has been shown to play a role in the regulation of choroidal neovascularization and vascular permeability. Anti-VEGF drugs have been shown to preserve or improve visual acuity by inhibiting vascular permeability and arresting the growth of neovascularization in the vast majority of treated patients. This review describes the current literature on the use of this therapeutic approach in the management of neovascular AMD and gives an overview of the future directions.
Keywords : Macular degeneration [drug therapy]; Age effect; Choroidal neovascularization [drug therapy]; Visual acuity [physiology]; Vascular endothelial growth factor A [antagonists & inhibitors]; Angiogenesis inhibitors [therapeutic use].