Abstract

ALMODIN, Juliana; BUHLER JUNIOR, Carlos; ALMODIN, Flavia  and  CVINTAL, Tadeu. Efficacy of fixed combination of timolol 10% and Brinzolamide 1%for primary open angle glaucoma and ocular hypertension. Rev. bras.oftalmol. [online]. 2012, vol.71, n.3, pp. 160-163. ISSN 0034-7280.  http://dx.doi.org/10.1590/S0034-72802012000300004.

OBJETICVE: To evaluate the efficacy and side effects of timolol 0,5% and brinzolamide 1% fixed combination in patients with primary open angle glaucoma (POAG) and ocular hypertension (OH). METHODS: 50 eyes of 26 patients with POAG or OH were evaluated with topical therapy with fixed combination of timolol 0.5% and brinzolamide 1%.The measurements with Goldmann tonometry were applied by only one ophthalmologist after 7 and 30 days on medication. The side effects were described by the patient based on the following question: "Did you feel any alteration with the prescribed drops?" The data were collected and analized statistically. RESULTS: The intraocular pressure (IOP) was lower in 7 and 30 days (p<0.001).The mean reduction in IOP was 38% with a variation from 23,8 mmhg to 14.6 and 14.4 mmhg in 7 and 30 days. Four patients had side effects: burning and blurring vision were related. CONCLUSION: the fixed combination of timolol 0.5% and brinzolamide 1% had good results with lower IOP in the treatment of patients with POAG and OH just like in the literature and had few side effects.

Keywords : Timolol [administration & dosage]; Glaucoma [drug therapy]; Drug combinations; Ocular hypertension.