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Revista Brasileira de Oftalmologia

Print version ISSN 0034-7280On-line version ISSN 1982-8551


SANTO, Artur Macaferri Del; AUGE, Renato Maluf  and  FERRAZ, Caroline Amaral. Preemptive analgesia of metamizole versus ibuprofen in retinal laser photocoagulation. Rev. bras.oftalmol. [online]. 2016, vol.75, n.1, pp.14-17. ISSN 0034-7280.


To compare the effectiveness of metamizole versus ibuprofen for the reduction of pain in retinal photocoagulation (RP).


A double-masked randomized controlled study was performed. Thirty-four patients with diabetic retinopathy were enrolled. The patients were randomized into two groups. Group A received oral 1000 mg metamizole. Group B received an oral intake of 600 mg ibuprofen. Pain during RP was assessed using a visual analog scale.


The mean pain scores for groups A and B were 5.2±2.6 and 4.5±1.4 (p=0.34). There were no significant differences in the mean pain scores between the two groups. The same is observed when analyzing by low, medium and high pain (p=0.09). The groups were similar in age and gender.


Both drugs were equivalents or equipotent in reduce ocular pain during retinal photocoagulation.

Keywords : Retinal laser photocoagulation; Pain; Analgesia; Retinopathy; Metamizole; Ibuprofen.

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