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Revista Brasileira de Oftalmologia

Print version ISSN 0034-7280On-line version ISSN 1982-8551


SIQUEIRA, Rubens Camargo  and  OREFICE, Fernando. The potential of the IGRA (Interferon Gamma Release Assay) test for the diagnosis of ocular tuberculosis . Review and comparative analysis with the tuberculosis skin test. Rev. bras.oftalmol. [online]. 2019, vol.78, n.3, pp.202-209.  Epub July 01, 2019. ISSN 0034-7280.

Precise detection of latent tuberculosis infection is becoming increasingly important due to increased use of immunosuppressive drugs and the human immunodeficiency virus epidemic , which increased the risk of reactivation to active tuberculosis (TB).The QuantiFERON® TB Gold IGRA Test has advantages over the skin test for TB, otherwise known as a Mantoux tuberculin test, for example, requires only a blood sample collection; there is no need for the patient to return to the laboratory for reading and interpretation of the results; The results are objective, do not require interpretation of the reader or interference of subjective criteria; it is an in vitro test, so there is no "booster effect" (potentiation of the tuberculin reaction); the test is not affected by prior BCG vaccination or infection with other species of mycobacteria. Limitations are described, although rare, as cross-reactions of this method with infections by some species of non-tuberculosis mycobacteria (including Mycobacterium kansasii, Mycobacterium szulgai and Mycobacterium marinum). There is still little data on the IGRA test in certain populations, such as in children, immunocompromised patients and pregnant women. In these groups, the interpretation of the test can be difficult and more studies are needed.

Keywords : IGRA; Quantiferon; PPD; Mantoux; Intradermal test; Tuberculosis; Uveitis.

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