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Revista Brasileira de Otorrinolaringologia

Print version ISSN 0034-7299


MAGALHAES, Sandra Lira Bastos de et al. Growth of cholesteatoma by implantation of epithelial tissue along the femoral bone of rats. Rev. Bras. Otorrinolaringol. [online]. 2005, vol.71, n.2, pp.188-191. ISSN 0034-7299.

Cholesteatoma is a well-known infection resembling a pearl. Its histological aspect is of an epidermal cyst formation characterized by epidermal-keratinized tissue in the middle ear and mastoid that can migrate and erode to adjacent structures. AIM: To verify epidermal cyst (cholesteatoma) growth through implantation of auricular skin of a mouse next to its femoral bone. STUDY DESIGN: experimental. MATERIAL AND METHOD: Ten healthy rats between two and five months of age and of both sexes underwent implantation of auricular skin on the femoral bone during a three-month period. Paraffin-embedded sections were obtained from the sample and stained with hematoxylin and eosin for pathology investigation. RESULTS: Macroscopic view: round soft yellowish granulation tissue. Microscopic view: keratinizing stratified squamous epithelium cystic formation. The cyst presented innermost corneal layer, resulted from keratinized skin, followed by granulated and squamous layers, and outermost basal layer. CONCLUSIONS: Growth of epidermal cyst (cholesteatoma) may start from a transplanted epithelial tissue next to the femoral bone of rats.

Keywords : cholesteatoma; epidermoid cyst; middle ear otitis.

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