SciELO - Scientific Electronic Library Online

vol.71 issue5A ten-year historic study of paranasal cavity endoscopy in patients with leprosyReliability of recognition thresholds of sentences in quiet and in noise author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Revista Brasileira de Otorrinolaringologia

Print version ISSN 0034-7299


AZEVEDO, Andréia A.  and  FIGUEIREDO, Ricardo R.. Tinnitus treatment with acamprosate: double-blind study. Rev. Bras. Otorrinolaringol. [online]. 2005, vol.71, n.5, pp.618-623. ISSN 0034-7299.

Nowadays, the treatment of tinnitus is still a great challenge for the otolaryngologists. Many facts remain unknown in its pathophysiology, leading to many different therapies, with irregular results. Acamprosate is a drug used in alcoholism treatment, due to its regulating effects in glutamatergic and GABA neurotransmission, and has never been used before in the treatment of tinnitus AIM: To evaluate efficacy and safety of the acamprosate in the treatment of sensorineural tinnitus. STUDY DESIGN: randomized clinical trial. MATERIAL AND METHOD: 50 patients with sensorineural tinnitus were divided into two groups: 25 received acamprosate and 25 placebo, for a period of 3 months, in a prospective double-blind study, being analyzed for its efficacy and safety by the subjective score from 1 to 10 given by the patient. RESULTS: We found a high index of success in the relief of tinnitus, about 86.9%. In 47.8% of the cases we found more than 50% relief. The incidence of side effects was low, 12%, all of them mild. CONCLUSION: Acamprosate, a drug used in the treatment of alcoholism, is a safe and successful alternative for sensorineural tinnitus' treatment.

Keywords : tinnitus; acamprosate.

        · abstract in Portuguese     · text in English | Portuguese     · English ( pdf epdf ) | Portuguese ( pdf epdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License