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Revista Brasileira de Otorrinolaringologia

versão impressa ISSN 0034-7299

Resumo

COSTA, Heloisa Juliana Zabeu Rossi; SILVA, Ciro Ferreira da; KORN, Gustavo Polacow  e  LAZARINI, Paulo Roberto. Posttraumatic facial nerve regeneration in rabbits. Rev. Bras. Otorrinolaringol. [online]. 2006, vol.72, n.6, pp.786-793. ISSN 0034-7299.  http://dx.doi.org/10.1590/S0034-72992006000600009.

Posttraumatic facial paralysis is a frequent disease. This work studies posttraumatic regeneration of the facial nerve in rabbits. Functional and histological analysis compared injured and normal nerves on opposite sides. The left facial nerve trunk of twenty rabbits were subjectedto compression lesion, and sacrificed after two (subgroup AL), four (BL) and six (CL) weeks. Comparison between groups was made by analysing total and partial densities of myelinated axons. STATISTICAL ANALYSIS: Tukey Method (p<0.05). RESULTS:There was partial functional recovery after two weeks, and complete recovery after five weeks. Qualitative analysis demonstrated a degenerative pattern in the AL group, with an increased tissue inflammatory process. Evident regeneration signs were observed in the BL group, and almost complete regeneration was seen in the CL group. Normal nerves (N) had an average TD of 15705.59 and average PD of 21800.75. The BL group had an average TD of 10818.55 and an average PD of 15340.56. The CL group had an average TD of 13920.36 and an average PD of 16589.15. The BL group had an average TD of N equal to 68.88%, and the CL group had an average TD of N equal to 88,63% (statistically significant). N showed a significant higher PD than injured nerves. However, this was not statistically different between BL and CL subgroups. Nerve DT was a more reliable method than PD in this study.

Palavras-chave : rabbits; nerve; facial; regeneration.

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