Revista Brasileira de Otorrinolaringologia
Print version ISSN 0034-7299
HORTA, Henrique de Lins e et al. Squamous cell carcinoma of the hypopharynx in a young woman with Fanconis anemia. Rev. Bras. Otorrinolaringol. [online]. 2006, vol.72, n.6, pp. 845-848. ISSN 0034-7299. http://dx.doi.org/10.1590/S0034-72992006000600018.
Fanconis anemia is a rare autosomal recessive disorder characterized by congenital malformation, bone marrow failure and genomic instability, with a predisposition to develop malignancies, especially the leukemias and upper aerodigestive tract tumors. Due to inherent characteristics to this syndrome, the treatment of such neoplasms is particularly difficult. In this paper we report the case of a 24-year-old woman with Fanconis anemia who developed a squamous cell carcinoma of the hypopharynx; she had none of the traditional risk factors, such as smoking and alcohol abuse. We also briefly review the literature about this topic
Keywords : fanconis anemia; squamous cell carcinoma; hypopharynx.