SciELO - Scientific Electronic Library Online

vol.75 issue1Assessing the impact adenotonsilectomy has on the lives of children with hypertrophy of palatine and pharyngeal tonsilsCorrelation analysis of the visual-analogue scale and the Tinnitus Handicap Inventory in tinnitus patients author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Revista Brasileira de Otorrinolaringologia

Print version ISSN 0034-7299


PINHEIRO NETO, Carlos Diógenes; WEBER, Raimar; ARAUJO-FILHO, Bernardo Cunha  and  MIZIARA, Ivan Dieb. Rhinosinusitis in HIV-infected children undergoing antiretroviral therapy. Rev. Bras. Otorrinolaringol. [online]. 2009, vol.75, n.1, pp.70-75. ISSN 0034-7299.

The association of protease inhibitors (PI) to antiretroviral therapy has generated sensible changes in morbidity and mortality of HIV-infected patients. AIM: Aims at evaluating the impact of this association on the prevalence of rhinosinusitis (RS) and CD4+ lymphocyte count in HIV-infected children. METHODS: Retrospective cross-sectional study of the medical charts of 471 HIV-infected children. In 1996, protease inhibitors were approved for use as an association drug in antiretroviral therapy. Children were divided into two groups: one which did not receive PI and another which received PI after 1996. The prevalence of RS and CD4+ lymphocyte counts were compared between these groups. RESULTS: 14.4% of HIV-infected children had RS. Chronic RS was more prevalent the its acute counterpart. Children under 6 years old who were taking protease inhibitors presented with a significant higher prevalence of acute RS. The association of PI with the antiretroviral regimen was associated to higher mean CD4+ lymphocyte count and lower prevalence of chronic RS. CONCLUSIONS: The use of protease inhibitors was associated to higher mean CD4+ lymphocyte count. Children under 6 years of age in antiretroviral therapy associated with PI presented a lower likelihood of developing chronic RS.

Keywords : children; haart; hiv infections; sinusitis.

        · abstract in Portuguese     · text in English | Portuguese     · English ( pdf epdf ) | Portuguese ( pdf epdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License