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Revista de Saúde Pública

Print version ISSN 0034-8910On-line version ISSN 1518-8787

Abstract

COSTA, Josiane Moreira da et al. Restrictive measure for the commercialization of antimicrobials in Brazil: results achieved. Rev. Saúde Pública [online]. 2019, vol.53, 68.  Epub Aug 19, 2019. ISSN 0034-8910.  http://dx.doi.org/10.11606/s1518-8787.2019053000879.

OBJECTIVE

To assess whether the incidence of hospital infection by a resistant microorganism decreased after the implementation of the restrictive measure of the National Health Surveillance Agency for the commercialization of antimicrobials.

METHODS

A historical cohort study of medical records of adult patients admitted to a general and public hospital from May 2010 to July 2011. A cohort was formed with patients admitted in the period before the restrictive measure for the commercialization of antimicrobials (Phase I) and a second cohort was formed with patients admitted after the implementation of the restrictive measure (Phase II).

RESULTS

The instantaneous risk of hospital infection by a resistant microorganism was estimated at seven by 1,000 people-time (95%CI 0.006–0.008) in Phase I, and four by 1,000 people-time (95%CI 0.003–0.005) in Phase II of the study. The differences between the survival curves in the different phases of the study and stratified by age group were also significant (p < 0.05).

CONCLUSIONS

The results suggest that the implementation of the restrictive measure of the commercialization of antimicrobials by the National Health Surveillance Agency reduced the incidence of hospital infection by a resistant microorganism.

Keywords : Anti-Bacterial Agents; Prescription Drug Overuse, legislation & jurisprudence; Drug Resistance, Microbial; Drug Monitoring; Pharmacovigilance.

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