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vol.26 issue4Chagas'disease serology in Brazil, 1975 — 1980Clinical and serologic features of 47 patients with paracoccidioidomycosis treated by amphotericin B author indexsubject indexarticles search
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Revista do Instituto de Medicina Tropical de São Paulo

On-line version ISSN 1678-9946

Abstract

WANKE, Bodo; PEDROSA, Paulo Nolasco; BRETAS, Gustavo Dos Santos  and  SETUBAL, Sérgio. Association of Amphotericin B and Rifampicin in the treatment of paracoccidioidomycosis. Report of efficacy in three cases. Rev. Inst. Med. trop. S. Paulo [online]. 1984, vol.26, n.4, pp.205-211. ISSN 1678-9946.  http://dx.doi.org/10.1590/S0036-46651984000400004.

Experimental data have shown that low concentration of amphotericin B disrupts of the fungal cellular membranes, enhancing entrance of rifampicin into citoplasm, where it acts specifically as an antifungal agent against Histoplasma capsulatum, Blastomyces dermatitidis and Candida albicans. Amphotericin B in half dosage combined with rifampicin is more effective than when used alone in full dosage. The Authors discuss the possible indications of this association in the therapy of paracoccidioidomycosis, and report its efficacy in three cases of this disease only controlled after its use.

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