Services on Demand
- Cited by Google
- Similars in SciELO
- Similars in Google
Revista do Instituto de Medicina Tropical de São Paulo
Print version ISSN 0036-4665
MAGALHAES, Albino Verbosa de et al. Histopathology of mucocutaneous leishmaniasis caused by Leishmania braziliensis braziliensis: 1. Histological patterns and evolutive study of the lesions. Rev. Inst. Med. trop. S. Paulo [online]. 1986, vol.28, n.4, pp. 253-262. ISSN 0036-4665. http://dx.doi.org/10.1590/S0036-46651986000400008.
The Authors describe the histopathological findings observed in biopsies from 378 cases of Mucocutaneous Leishmaniasis, caused by Leishmania braziliensis braziliensis. All the patients lived in the locality of Três Braços, State of Bahia, an endemic area of Leishmaniasis in Brazil. Parasites were found in 63.7% of patients with cutaneous form and in 35.7% of cases with mucous lesions, although always in reduced number. Histopathologic findings allowed the caracterization of five different patterns: 1. Exsudative-cellular reaction, due to infiltraction of histiocytes, lymphocytes and plasm cells; 2. Exsudative-necrotic reaction, characterized by the association of necrosis with cellular infiltration; 3. Exsudative and necrotic-granulomatous reaction, corresponding to pattern described as chronic-granulomatous inflammation with necrosis; 4. Exsudativegranulomatous reaction, characterized a disorganized granulomatous reaction, without tissue necrosis; 5. Exsudative-tuberculoid reaction — in which a typical tuberculoid granuloma is formed. The follow-up study in 49 patients showed, in sucessive biopsies, changes in the histopathologic patterns in 63.2% of cutaneous forms and in 45.4% of the mucous forms. It was concluded that the exsudative-cellular reaction represents both the inicial and final pattern of Mucocutaneous Leishmaniasis lesion. The other four histopathologic patterns characterize intermediate forms found during the evolution of the disease.
Keywords : Leishmaniose cutâneo; Mucosa; Leishmania brasiliensis; Padrões histopatológicos; Evolução histopatoldgicas das lesões.