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Revista do Instituto de Medicina Tropical de São Paulo

On-line version ISSN 1678-9946

Abstract

TAVARES, Paulo et al. Changes of rabbit pulmonary elastic properties and bronchomotrlclty in experimentally induced chronic Chagas' disease. Rev. Inst. Med. trop. S. Paulo [online]. 1986, vol.28, n.5, pp.325-329. ISSN 1678-9946.  http://dx.doi.org/10.1590/S0036-46651986000500007.

In order to study the role of bronchial denervation in Chagas' disease, the mechanical properties and the hronchomotricity o£ 6 chronic chagasic and 4 control rabbits were investigated. The whole-body plethysmograph method was used and the measurements were performed before and after intravenous administration of histamine chlorhydrate (0.11 mg/kg body weight). A smaller increase of the functional residual capacity, an almost unchanged peak passive expiratory flow after the histamine administration and a shift to the right of the static transpulmonary pressure/volume curve observed in the chagasic animals indicate an alteration of the bronchial tree, mainly consisting of a decreased bronehoreactivity.

Keywords : Experimental trypanosomiasis; Rabbit; Changes in pulmonary; Elastic properties.

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